Meher Mukesh Kumar, Poluri Krishna Mohan
Department of Biotechnology, Indian Institute of Technology Roorkee (IIT-Roorkee), Roorkee 247667, Uttarakhand, India.
Department of Biotechnology, Indian Institute of Technology Roorkee (IIT-Roorkee), Roorkee 247667, Uttarakhand, India; Centre for Nanotechnology, Indian Institute of Technology Roorkee (IIT-Roorkee), Roorkee 247667, Uttarakhand, India.
Carbohydr Polym. 2021 Aug 15;266:118124. doi: 10.1016/j.carbpol.2021.118124. Epub 2021 Apr 28.
Synthesis and characterization of nanoparticles with different morphologies coupled to minimal chemical interventions for sustainable applications is one of the contemporary topics in the field of nanotechnology. In the current study, heparinized silver nanoparticles were synthesized using a chemical reduction method. Different concentrations of heparin were used to investigate its role in the stability and morphological properties of silver nanoparticles. Interestingly, it has been observed that the concentration of the stabilizing agent heparin plays a pivotal role in dictating the size and shape of the nanosilver. As visualized under a transmission electron microscope, nanosilver with different morphological states such as triangles, truncated triangles, hexagon, and spheres has been experimentally trapped. Such modular property of heparin coated nanosilver has also exhibited substantial differences in their anticoagulation and antimicrobial activities.
合成具有不同形态的纳米颗粒并结合最少化学干预以实现可持续应用，是纳米技术领域的当代主题之一。在当前研究中，采用化学还原法合成了肝素化银纳米颗粒。使用不同浓度的肝素研究其在银纳米颗粒稳定性和形态特性中的作用。有趣的是，已观察到稳定剂肝素的浓度在决定纳米银的尺寸和形状方面起着关键作用。在透射电子显微镜下观察到，实验捕获了具有不同形态状态的纳米银，如三角形、截顶三角形、六边形和球形。肝素包覆纳米银的这种模块化特性在其抗凝和抗菌活性方面也表现出显著差异。
