Laboratory of Toxicology LATOX, Department of Analysis, Pharmacy Faculty, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Mutat Res. 2013 Jun 14;754(1-2):63-70. doi: 10.1016/j.mrgentox.2013.04.008. Epub 2013 Apr 27.
We evaluated genotoxic effects of exposure to low levels of benzene, a class I human carcinogen, among gasoline station attendants (GSA). Oxidative stress and the protective effects of antioxidants on DNA damage were also analyzed. Although exposures were below ACGIH (American Conference of Governmental Industrial Hygienists) limits, the GSA group presented higher DNA damage indices and micronucleus frequencies, increased oxidative protein damage, and decreased antioxidant capacity relative to the control group. Duration of benzene exposure was correlated with DNA and protein damage. The biomarkers evaluated in this work may provide early signals of damage in subjects occupationally exposed to benzene.
我们评估了加油站工作人员（GSA）接触低水平苯（一类人类致癌物）的遗传毒性效应。同时还分析了氧化应激和抗氧化剂对 DNA 损伤的保护作用。尽管接触量低于美国政府工业卫生学家会议（ACGIH）的限值，但 GSA 组的 DNA 损伤指数和微核频率更高，氧化蛋白损伤增加，抗氧化能力降低，与对照组相比。苯暴露时间与 DNA 和蛋白质损伤相关。本研究中评估的生物标志物可能为职业性苯暴露人群的早期损伤提供信号。
