遗传性肥胖大鼠和饮食诱导肥胖小鼠的凝血时间缩短。
Shortened blood coagulation times in genetically obese rats and diet-induced obese mice.
作者信息
Kaji Noriyuki, Nagakubo Dai, Hashida Shin-Ichi, Takahashi Saya, Kuratani Motoi, Hirai Norihiko, Shirai Mitsuyuki, Asai Fumitoshi
机构信息
Department of Pharmacology, Azabu University School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
出版信息
J Vet Med Sci. 2013;75(9):1245-8. doi: 10.1292/jvms.13-0029. Epub 2013 Apr 26.
The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
本研究的目的是调查遗传性肥胖大鼠和饮食诱导肥胖（DIO）小鼠的凝血时间，以阐明内脏肥胖与凝血之间的关系。遗传性肥胖模型WBN/Kob-Lepr(fa)（fa/fa）大鼠与年龄匹配的Wistar大鼠相比，活化部分凝血活酶时间（aPTT）和凝血酶原时间（PT）显著缩短。饮食诱导肥胖模型C57BL/6J小鼠喂食高脂饮食（60%），与喂食标准饮食的瘦小鼠相比，aPTT、PT和凝血酶时间显著缩短。fa/fa大鼠和DIO小鼠还具有更高的体重、内脏脂肪重量和胰岛素抵抗。这些结果表明，除了葡萄糖和脂质代谢紊乱外，内脏肥胖还与凝血加速有关。
Zotero 插件