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果蝇肠道上皮细胞探测细菌的机制及其后果。

Mechanisms and consequence of bacteria detection by the Drosophila gut epithelium.

机构信息

Aix-Marseille Université, CNRS, Institut de Biologie du Développement de Marseille-Luminy UMR CNRS 7288, Marseille, France.

出版信息

Gut Microbes. 2013 May-Jun;4(3):259-63. doi: 10.4161/gmic.24386. Epub 2013 Apr 12.

DOI:10.4161/gmic.24386
PMID:23633672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3669173/
Abstract

Since insect mostly developed on decaying matter and contaminated fruits, they are constantly ingesting bacteria. The insect model, Drosophila, is therefore well adapted to study the interactions that take place between the gut epithelia and either resident or infectious bacteria. In order to provide an ad hoc immune response, gut epithelial cells must detect the presence of bacteria. In a recent report, Bosco-Drayon et al. identify the main receptors by which Drosophila sense gut associated bacteria and analyze how this bacteria-receptor interaction translate into gene activation.

摘要

由于昆虫大多在腐烂物质和受污染的水果上发育，因此它们会不断摄入细菌。昆虫模型果蝇因此非常适合研究肠道上皮细胞与常驻或传染性细菌之间发生的相互作用。为了提供特定的免疫反应，肠道上皮细胞必须检测细菌的存在。在最近的一份报告中，Bosco-Drayon 等人确定了果蝇感知肠道相关细菌的主要受体，并分析了这种细菌-受体相互作用如何转化为基因激活。

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本文引用的文献

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The complementary facets of epithelial host defenses in the genetic model organism Drosophila melanogaster: from resistance to resilience.遗传模式生物果蝇中上皮宿主防御的互补方面：从抵抗到弹性。
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Cell Host Microbe. 2012 Aug 16;12(2):153-65. doi: 10.1016/j.chom.2012.06.002.
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Tissue- and ligand-specific sensing of gram-negative infection in drosophila by PGRP-LC isoforms and PGRP-LE.PGRP-LC 同工型和 PGRP-LE 通过组织和配体特异性感应果蝇中的革兰氏阴性感染。
J Immunol. 2012 Aug 15;189(4):1886-97. doi: 10.4049/jimmunol.1201022. Epub 2012 Jul 6.
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Immunity. 2011 Nov 23;35(5):770-9. doi: 10.1016/j.immuni.2011.09.018.
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