Abbasinazari Mohammad, Sahraee Zahra, Mirahmadi Maryam
Department of Clinical Pharmacy, Shahid Beheshti University of Medical Sciences , Tehran, Iran .
J Clin Diagn Res. 2013 Mar;7(3):462-6. doi: 10.7860/JCDR/2013/4673.2799. Epub 2013 Mar 1.
Helicobacter pylori is a major cause of upper gastrointestinal disorders. The eradication of H. pylori has been recommended for the treatment of different gastrointestinal diseases. Notwithstanding, a combination therapy is needed for Helicobacter pylori eradication, but using these medications can be the cause, the incidence risk of patients' adherence to treatment regimens reduction and probably increase risk of Adverse Drug Reactions (ADRS), so, it is seem that evaluation the out come of combination therapy is need more than the past.
The aim of present study was to determine the patients' adherence to the treatment and the ADRs with five eradiation regimens.
A cross sectional study was done in a well known referral clinic of gastrointestinal disorders in Tehran, Iran.
Ninety patients were evaluated the study (18 in each of the five regimens). The adherence to the treatment and the ADRs of the patients were asked during the treatment, twice, by doing telephone assays.
The data were analyzed by using the SPSS, 17 software and the statistical significance was accepted for the P values of 0.05.
81% of the patients had a good adherence and there was no significant difference between the types of regimens (triple or quadruple therapy) and the adherence to the treatment regimens by the patients (p=0.6). Also, we found that there was no significant relationship between the types of regimens and the sex (p=0.99), education level (p=0.99), accommodation (p=0.93), an existence of underlying disease (p=0.86) and the concurrent use other medications (p=0.93). But there was a significant relationship between the patients' age and adherence to the treatment regimens (p=0.008). The most reported ADRs belonged to gastrointestinal (GI) disorders (an abnormal taste had the most prevalence (36.6%) among the GI disorders). There was no significant relationship between the regimen type and the GI ADRs, (p=0.48).
The findings of this study showed that the patients' adherence to the treatment regimens and the ADRs did not have a significant relationship with the various eradication regimens for H. pylori. It seems that the type of H. pylori eradication regimen may not be an important factor in the patients' adherence to the treatment regimens and the ADRs.
幽门螺杆菌是上消化道疾病的主要病因。对于不同的胃肠道疾病，推荐根除幽门螺杆菌。尽管如此，根除幽门螺杆菌需要联合治疗，但使用这些药物可能会导致患者对治疗方案的依从性降低，并且可能增加药物不良反应（ADR）的风险，所以，似乎比以往更需要评估联合治疗的效果。
本研究的目的是确定患者对五种根除方案的治疗依从性和药物不良反应。
在伊朗德黑兰一家著名的胃肠道疾病转诊诊所进行了一项横断面研究。
对90名患者进行了研究评估（五种方案各18名）。在治疗期间通过电话检测询问患者两次，了解其治疗依从性和药物不良反应。
使用SPSS 17软件对数据进行分析，P值小于0.05具有统计学意义。
81%的患者依从性良好，方案类型（三联或四联疗法）与患者对治疗方案的依从性之间无显著差异（p = 0.6）。此外，我们发现方案类型与性别（p = 0.99）、教育水平（p = 0.99）、居住条件（p = 0.93）、是否存在基础疾病（p = 0.86）以及是否同时使用其他药物（p = 0.93）之间均无显著关系。但患者年龄与治疗方案依从性之间存在显著关系（p = 0.008）。报告最多的药物不良反应属于胃肠道（GI）疾病（在胃肠道疾病中，味觉异常最为常见（36.6%））。方案类型与胃肠道药物不良反应之间无显著关系（p = 0.48）。
本研究结果表明，患者对治疗方案的依从性和药物不良反应与幽门螺杆菌的各种根除方案无显著关系。似乎幽门螺杆菌根除方案的类型可能不是影响患者对治疗方案依从性和药物不良反应的重要因素。
