来自节丛孢属严格种的阿克拉霉素是 N(2)，3-亚乙基-2'-异丙基-1-甲基鸟嘌呤，而不是 1H-氮丙啶。合成与结构修订。
Acremolin from Acremonium strictum is N(2),3-etheno-2'-isopropyl-1-methylguanine, not a 1H-azirine. Synthesis and structural revision.
机构信息
Department of Chemistry and Biochemistry, and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , 9500 Gilman Drive MC0358, La Jolla, California 92093, United States.
出版信息
Org Lett. 2013 May 17;15(10):2370-3. doi: 10.1021/ol400752s. Epub 2013 May 1.
Abstract
The first synthesis of the heterocyclic marine natural product, acremolin, is reported along with the revision of the structure from a 1H-azirine to a substituted N(2),3-ethenoguanine (5-methyl-7-isopropyl-4,5-dihydroimidazo[2,1-b]purine). Additional properties of acremolin are also described including its (1)H-(15)N-HMBC and fluorescence spectra.
摘要
本文首次报道了杂环海洋天然产物 acremolin 的全合成，并将其结构从 1H-氮丙啶修订为取代的 N(2)，3-亚乙基鸟嘌呤（5-甲基-7-异丙基-4,5-二氢咪唑并[2,1-b]嘌呤）。还描述了 acremolin 的其他性质，包括其 (1)H-(15)N-HMBC 和荧光光谱。
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