Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, USA.
Physiology (Bethesda). 2013 May;28(3):199-209. doi: 10.1152/physiol.00004.2013.
Phosphorylation of mitochondrial proteins has emerged as a major regulatory mechanism for metabolic adaptation. cAMP signaling and PKA phosphorylation of mitochondrial proteins have just started to be investigated, and the presence of cAMP-generating enzymes and PKA inside mitochondria is still controversial. Here, we discuss the role of cAMP in regulating mitochondrial bioenergetics through protein phosphorylation and the evidence for soluble adenylyl cyclase as the source of cAMP inside mitochondria.
线粒体蛋白的磷酸化已成为代谢适应的主要调节机制。cAMP 信号和 PKA 对线粒体蛋白的磷酸化作用才刚刚开始被研究，而 cAMP 生成酶和 PKA 存在于线粒体内部仍然存在争议。在这里，我们讨论了 cAMP 通过蛋白磷酸化调节线粒体生物能学的作用，以及可溶性腺苷酸环化酶作为线粒体内部 cAMP 来源的证据。
