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中国南方病猪中H1N1猪流感病毒的分离与系统发育分析

Isolation and Phylogenetic Analysis of H1N1 Swine Influenza Virus from Sick Pigs in Southern China.

作者信息

Kong Wei-Li, Huang Yu-Mao, Cao Nan, Qi Hai-Tao, Huang Liang-Zong, Zhao Meng-Meng, Guan Shang-Song, Wang Wen-Hua, Zhao Fu-Rong, Qi Wen-Bao, Jiao Pei-Rong, Zhang Gui-Hong

机构信息

College of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642 China.

出版信息

Indian J Virol. 2011 Jun;22(1):66-71. doi: 10.1007/s13337-011-0035-2. Epub 2011 May 25.

DOI:10.1007/s13337-011-0035-2
PMID:23637505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3550729/
Abstract

Two swine influenza (SI) H1N1 virus was isolated from a pig during a severe outbreak of respiratory disease in south China. The two H1N1 influenza viruses were classical SI virus. A/swine/Guangdong/L6/09 is classical SI virus of recent years, which is of the main SI virus in China. Howere, A/swine/Guangdong/L3/09 was closet to A/swine/Iowa/1931, which was the first isolated SI virus and had demonstrated significant pathogenicity in animal models. The results of phylogenetic analysis of A/swine/Guangdong/L3/09 showed a close relationship with the 1918 pandemic virus. The results suggested that the previous SI virus appeared again. Whether, it brought a new pandemic to pigs deserves more attention.

摘要

在中国南方一场严重的呼吸道疾病暴发期间,从一头猪身上分离出两株甲型H1N1猪流感(SI)病毒。这两株H1N1流感病毒均为经典猪流感病毒。A/猪/广东/L6/09是近年来的经典猪流感病毒,是中国主要的猪流感病毒之一。然而,A/猪/广东/L3/09与A/猪/爱荷华/1931最为接近,后者是最早分离出的猪流感病毒,且已在动物模型中显示出显著的致病性。对A/猪/广东/L3/09的系统发育分析结果显示,它与1918年大流行病毒关系密切。结果表明,先前的猪流感病毒再次出现。它是否会给猪带来新的大流行值得更多关注。

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