中国猪群中甲型H1N1禽流感病毒的出现。
Emergence of avian H1N1 influenza viruses in pigs in China.
作者信息
Guan Y, Shortridge K F, Krauss S, Li P H, Kawaoka Y, Webster R G
机构信息
Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
J Virol. 1996 Nov;70(11):8041-6. doi: 10.1128/JVI.70.11.8041-8046.1996.
Abstract
Avian influenza A viruses from Asia are recognized as the source of genes that reassorted with human viral genes to generate the Asian/57 (H2N2) and Hong Kong/68 (H3N2) pandemic strains earlier in this century. Here we report the genetic analysis of avian influenza A H1N1 viruses recently isolated from pigs in southern China, a host suspected to generate new pandemic strains through gene reassortment events. Each of the eight gene segments was of avian origin. Phylogenetic analysis indicates that these genes form an Asian sublineage of the Eurasian avian lineage, suggesting that these viruses are an independent introduction into pigs in Asia. The presence of avian influenza viruses in pigs in China places them in an optimal position for transmission to humans and may serve as an early warning of the emergence of the next human influenza virus pandemic.
摘要
来自亚洲的甲型禽流感病毒被认为是基因来源，这些基因在本世纪早些时候与人类病毒基因重配，产生了亚洲/57（H2N2）和香港/68（H3N2）大流行毒株。在此，我们报告了最近从中国南方猪只中分离出的甲型H1N1禽流感病毒的基因分析，猪被怀疑是通过基因重配事件产生新的大流行毒株的宿主。八个基因片段中的每一个均源自禽类。系统发育分析表明，这些基因形成了欧亚禽类谱系的一个亚洲亚系，这表明这些病毒是独立传入亚洲猪群的。中国猪群中存在禽流感病毒，使其处于向人类传播的最佳位置，并可能作为下一次人类流感病毒大流行出现的早期预警。
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Analysis of the influenza virus gene pool of avian species from southern China.中国南方禽类流感病毒基因库分析。
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