Thukkani Arun K, Jaffer Farouc A
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School 70 Francis Street, Boston, MA 02115, USA.
Am J Nucl Med Mol Imaging. 2013 Apr 9;3(3):217-31. Print 2013.
Novel imaging modalities are required to better identify vulnerable atherosclerotic plaques before their dire consequences of myocardial infarction, sudden death, and stroke. Moving beyond traditional diagnostic methods, the field of molecular imaging offers an innovative approach to report upon critical in vivo biological features of high-risk plaques. Molecular imaging employs engineered, targeted imaging agents in conjunction with sophisticated, high-resolution detection systems. While various modalities have been investigated for this purpose, intravascular near infrared fluorescence imaging (NIRF) strategies are uniquely poised to provide high-resolution readouts of human coronary artery plaques. To date, preclinical animal studies have demonstrated feasibility of both standalone NIRF intravascular imaging as well as dual-modality approaches detecting inflammation and fibrin deposition in coronary-sized arteries. This translatable catheter-based approach is positioned to advance the identification of biologically vulnerable coronary plaques and coronary stents at risk of thrombosis.
需要新的成像方式来在心肌梗死、猝死和中风等严重后果出现之前更好地识别易损动脉粥样硬化斑块。超越传统诊断方法，分子成像领域提供了一种创新方法来报告高危斑块的关键体内生物学特征。分子成像采用工程化的靶向成像剂结合精密的高分辨率检测系统。虽然已针对此目的研究了各种成像方式，但血管内近红外荧光成像（NIRF）策略特别适合提供人类冠状动脉斑块的高分辨率读数。迄今为止，临床前动物研究已证明独立的NIRF血管内成像以及检测冠状动脉大小动脉中的炎症和纤维蛋白沉积的双模态方法的可行性。这种基于导管的可转化方法有望推进对有血栓形成风险的生物学易损冠状动脉斑块和冠状动脉支架的识别。
