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玻璃体腔注射贝伐单抗联合Nd:YAG激光玻璃体后脱离术治疗瓦氏动作相关性黄斑前出血并观察内界膜变化:一项海德堡视网膜断层扫描研究

Combine intravitreal bevacizumab with Nd: YAG laser hyaloidotomy for valsalva pre-macular haemorrhage and observe the internal limiting membrane changes: a spectralis study.

作者信息

Hua Rui, Liu Li-Min, Hu Yue-Dong, Zhou Yun, Chen Lei

机构信息

Department of Ophthalmology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.

出版信息

Int J Ophthalmol. 2013 Apr 18;6(2):242-5. doi: 10.3980/j.issn.2222-3959.2013.02.25. Print 2013.

Abstract

Valsalva retinopathy was described as a particular form of retinopathy, pre-retinal and subinternal limiting membrane haemorrhages in nature that rarely may break through and become subhyloid or intravitreal, secondary to a sudden increase in intrathoracic pressure. We reported a new way that Nd:YAG laser for ILM hyaloidotomy in order to drain the sub-ILM blood into vitreous cavity combined with intravitreal bevacizumab to improve the absorption of blood. Therapeutic alliance make significant outcome, protecting vision in time. We used spectralis OCT to observe sub-ILM mix cells and special ILM structure in this lesion for the first time, as the spectralis OCT can reach histology level imagination.

摘要

瓦尔萨尔瓦视网膜病变被描述为一种特殊形式的视网膜病变,本质上是视网膜前和内界膜下出血,很少会突破并变成玻璃膜下或玻璃体内出血,继发于胸腔内压力突然升高。我们报告了一种新方法,即使用Nd:YAG激光进行内界膜玻璃体切割术,以便将内界膜下的血液引流到玻璃体腔,并联合玻璃体腔内注射贝伐单抗以促进血液吸收。联合治疗取得了显著效果,及时保护了视力。我们首次使用光谱域光学相干断层扫描(Spectralis OCT)观察该病变内界膜下的混合细胞和特殊的内界膜结构,因为光谱域光学相干断层扫描可以达到组织学水平的成像。

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Spectral-domain OCT evaluation of Nd:YAG laser treatment for Valsalva retinopathy.谱域 OCT 评估 Nd:YAG 激光治疗 Valsalva 视网膜病变。
Graefes Arch Clin Exp Ophthalmol. 2010 Apr;248(4):599-601. doi: 10.1007/s00417-009-1252-x. Epub 2009 Dec 8.
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Nd:YAG laser hyaloidotomy for valsalva pre-macular haemorrhage.Nd:YAG 激光玻璃体切割术治疗 Valsalva 黄斑前出血。
Ir J Med Sci. 2011 Sep;180(3):749-52. doi: 10.1007/s11845-009-0355-z. Epub 2009 Jun 3.

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