National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Southampton, Hampshire, UK.
BMJ Open. 2013 May 2;3(5):e002521. doi: 10.1136/bmjopen-2012-002521.
This study aimed to investigate what percentage of National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Programme-funded projects have published their final reports in the programme's journal HTA and to explore reasons for non-publication.
Retrospective cohort study.
Failure to publish findings from research is a significant area of research waste. It has previously been suggested that potentially over 50% of studies funded are never published.
All NIHR HTA projects with a planned submission date for their final report for publication in the journal series on or before 9 December 2011 were included.
The projects were classified according to the type of research, whether they had been published or not; if not yet published, whether they would be published in the future or not. The reasons for non-publication were investigated.
628 projects were included: 582 (92.7%) had published a monograph; 19 (3%) were expected to publish a monograph; 13 (2.1%) were discontinued studies and would not publish; 12 (1.9%) submitted a report which did not lead to a publication as a monograph; and two (0.3%) did not submit a report. Overall, 95.7% of HTA studies either have published or will publish a monograph: 94% for those commissioned in 2002 or before and 98% for those commissioned after 2002. Of the 27 projects for which there will be no report, the majority (21) were commissioned in 2002 or before. Reasons why projects failed to complete included failure to recruit; issues concerning the organisation where the research was taking place; drug licensing issues; staffing issues; and access to data.
The percentage of HTA projects for which a monograph is published is high. The advantages of funding organisations requiring publication in their own journal include avoidance of publication bias and research waste.
本研究旨在调查英国国家卫生与临床优化研究所（NIHR）卫生技术评估（HTA）计划资助的项目中，有多少项目在该计划的期刊 HTA 上发表了最终报告，并探讨未发表的原因。
回顾性队列研究。
未能发表研究结果是研究浪费的一个重要领域。此前有人提出，超过 50%的资助研究从未发表过。
所有计划于 2011 年 12 月 9 日或之前提交最终报告供期刊系列发表的 NIHR HTA 项目均被纳入研究。
根据研究类型对项目进行分类，无论是否已发表；如果尚未发表，未来是否会发表。调查了未发表的原因。
共纳入 628 个项目：582 个（92.7%）已发表专着；19 个（3%）预计将发表专着；13 个（2.1%）为已终止的研究，不会发表；12 个（1.9%）提交的报告未作为专着发表；2 个（0.3%）未提交报告。总体而言，95.7%的 HTA 研究已经或将要发表专着：2002 年或之前委托的研究占 94%，2002 年之后委托的研究占 98%。在 27 个不会有报告的项目中，大多数（21 个）是在 2002 年或之前委托的。项目未能完成的原因包括招募失败；研究进行地组织的问题；药物许可问题；人员配备问题；以及数据获取问题。
发表专着的 HTA 项目比例很高。资助机构要求在自己的期刊上发表的优点包括避免发表偏倚和研究浪费。
