Department of Organic and Applied Chemistry, Faculty of Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland.
Eur J Med Chem. 2013 Jun;64:389-95. doi: 10.1016/j.ejmech.2013.04.023. Epub 2013 Apr 16.
In this work we reported the synthesis and evaluation of in vitro antimicrobial activities of hydrazones 6 obtained from 3-oxido-1H-imidazole-4-carbohydrazides 4. All new compounds were characterized by spectroscopic methods. Hydrazones 6 were tested for their in vitro antimicrobial activity against four Gram-positive and four Gram-negative strains of bacteria as well as one fungal species. Three of the tested compounds appeared to be promising agents against reference strains of Escherichia coli, Staphylococcus aureus and Staphylococcus epidermidis. They were also tested against twelve clinical isolates of S. aureus and their cytotoxic effect on murine fibroblasts and HeLa human tumor cell line was determined.
在这项工作中，我们报道了从 3-氧代-1H-咪唑-4-甲酰肼 4 得到的腙 6 的合成和体外抗菌活性评价。所有新化合物均通过光谱方法进行了表征。腙 6 对四种革兰氏阳性和四种革兰氏阴性细菌菌株以及一种真菌进行了体外抗菌活性测试。测试的三种化合物似乎对大肠杆菌、金黄色葡萄球菌和表皮葡萄球菌的参考菌株具有良好的抗菌效果。它们还针对十二株金黄色葡萄球菌的临床分离株进行了测试，并测定了它们对小鼠成纤维细胞和人宫颈癌细胞系 HeLa 的细胞毒性作用。
