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Isoprenoid biosynthesis: ferraoxetane or allyl anion mechanism for IspH catalysis?

作者信息

Li Jikun, Wang Ke, Smirnova Tatyana I, Khade Rahul L, Zhang Yong, Oldfield Eric

机构信息

Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL 61801, USA.

出版信息

Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6522-5. doi: 10.1002/anie.201302343. Epub 2013 May 6.

Abstract
摘要

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本文引用的文献

1
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.
J Am Chem Soc. 2012 Jul 11;134(27):11225-34. doi: 10.1021/ja303445z. Epub 2012 Jun 28.
3
The stereochemical course and mechanism of the IspH reaction.
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4053-7. doi: 10.1002/anie.201201110. Epub 2012 Mar 12.
4
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis.
J Mol Biol. 2012 Feb 10;416(1):1-9. doi: 10.1016/j.jmb.2011.11.033. Epub 2011 Nov 23.
5
Terpene biosynthesis: modularity rules.
Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1124-37. doi: 10.1002/anie.201103110. Epub 2011 Nov 21.
6
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.
J Am Chem Soc. 2011 Jun 8;133(22):8400-3. doi: 10.1021/ja200763a. Epub 2011 May 16.
7
Reductive dehydroxylation of allyl alcohols by IspH protein.
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
9
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11189-93. doi: 10.1073/pnas.1000264107. Epub 2010 Jun 7.

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