Isoprenoid biosynthesis: ferraoxetane or allyl anion mechanism for IspH catalysis?
作者信息
Li Jikun, Wang Ke, Smirnova Tatyana I, Khade Rahul L, Zhang Yong, Oldfield Eric
机构信息
Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL 61801, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jun 17;52(25):6522-5. doi: 10.1002/anie.201302343. Epub 2013 May 6.
Abstract
摘要
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本文引用的文献
1
Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation.自由基是否参与 IspH 催化作用？EPR 和晶体学研究。
J Am Chem Soc. 2012 Jul 11;134(27):11225-34. doi: 10.1021/ja303445z. Epub 2012 Jun 28.
2
A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.深入研究野生型和突变型（E）-4-羟基-3-甲基-2-丁烯基二磷酸还原酶中可能的反应中间体的光谱性质。
Biochemistry. 2012 Jun 19;51(24):4835-49. doi: 10.1021/bi3001215. Epub 2012 Jun 7.
3
The stereochemical course and mechanism of the IspH reaction.IspH反应的立体化学过程和机制。
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4053-7. doi: 10.1002/anie.201201110. Epub 2012 Mar 12.
4
Crystal structures of mutant IspH proteins reveal a rotation of the substrate's hydroxymethyl group during catalysis.突变 IspH 蛋白的晶体结构揭示了催化过程中底物羟甲基基团的旋转。
J Mol Biol. 2012 Feb 10;416(1):1-9. doi: 10.1016/j.jmb.2011.11.033. Epub 2011 Nov 23.
5
Terpene biosynthesis: modularity rules.萜类化合物生物合成：模块化规则。
Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1124-37. doi: 10.1002/anie.201103110. Epub 2011 Nov 21.
6
An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis.IspG（GcpE）催化反应中间体的 ENDOR 和 HYSCORE 研究。
J Am Chem Soc. 2011 Jun 8;133(22):8400-3. doi: 10.1021/ja200763a. Epub 2011 May 16.
7
Reductive dehydroxylation of allyl alcohols by IspH protein.异戊烯基二磷酸脱水酶蛋白催化烯丙醇的还原脱羟反应。
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8802-9. doi: 10.1002/anie.201000833.
8
Paramagnetic intermediates of (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE/IspG) under steady-state and pre-steady-state conditions.(E)-4-羟基-3-甲基-2-丁烯基二磷酸合酶（GcpE/IspG）在稳态和预稳态条件下的顺磁中间产物。
J Am Chem Soc. 2010 Oct 20;132(41):14509-20. doi: 10.1021/ja101764w.
9
Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG).4Fe-4S 异戊烯基生物合成蛋白 GcpE（IspG）的有机金属作用机制和抑制作用。
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11189-93. doi: 10.1073/pnas.1000264107. Epub 2010 Jun 7.
10
Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms.Fe(4)S(4)- 簇蛋白 IspH（LytB）的抑制作用：电子顺磁共振、金属环和机制。
J Am Chem Soc. 2010 May 19;132(19):6719-27. doi: 10.1021/ja909664j.
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