Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Curr Eye Res. 2013 Sep;38(9):959-64. doi: 10.3109/02713683.2013.794246.
To evaluate total antioxidant status (TAS) in the plasma of primary open angle glaucoma (POAG) patients and to compare it to that of the control group. Additionally, we aim to investigate the association of various POAG clinical indices with TAS level.
Plasma samples were obtained from 139 POAG patients and 148 glaucoma-free controls of matching age, sex, and ethnicity. TAS in all samples was determined by spectrophotometric and enzyme-linked immunosorbent assay methods.We studied the possible association of the TAS level with various clinical indices relevant to POAG.
The mean (±SD) total antioxidant (TAS) value was lower among patients: 0.47 (±0.32), than controls: 0.97 (±0.43) and this difference was statistically significant (p<0.0001). TAS concentration was not significantly associated neither with the level of intraocular pressure, nor with number of anti-glaucoma medications (p = 0.532 and 0.084 respectively). However, TAS level shows a trend towards reduction with increased severity of glaucoma presented in a reversed significant association with cup/disc ratio (p = 0.043).
Our findings provide evidence that TAS decreases in the plasma of POAG patients and that it may play a role in POAG pathogenesis. Association of TAS level with increased cup-to-disc ratio highlights TAS potential role as a predictive-marker for POAG-severity.
评估原发性开角型青光眼（POAG）患者血浆中的总抗氧化状态（TAS），并将其与对照组进行比较。此外，我们旨在研究各种 POAG 临床指标与 TAS 水平的相关性。
从 139 名 POAG 患者和 148 名年龄、性别和种族匹配的无青光眼对照组中获取血浆样本。使用分光光度法和酶联免疫吸附试验法测定所有样本中的 TAS。我们研究了 TAS 水平与与 POAG 相关的各种临床指标的可能相关性。
患者的平均（±SD）总抗氧化（TAS）值较低：0.47（±0.32），而对照组为 0.97（±0.43），差异具有统计学意义（p<0.0001）。TAS 浓度与眼内压水平或抗青光眼药物的数量均无显著相关性（p = 0.532 和 0.084 分别）。然而，TAS 水平随着杯盘比的增加而呈下降趋势，呈反向显著相关性（p = 0.043）。
我们的研究结果表明，POAG 患者的血浆 TAS 降低，它可能在 POAG 的发病机制中发挥作用。TAS 水平与杯盘比增加的相关性突显了 TAS 作为 POAG 严重程度的预测标志物的潜在作用。
