Abu-Amero Khaled K, Azad Taif Anwar, Mousa Ahmed, Osman Essam A, Sultan Tahira, Al-Obeidan Saleh A
Department of Ophthalmology, College of Medicine, King Saud University, PO Box 245, Riyadh 11411, Saudi Arabia.
BMC Res Notes. 2014 Mar 19;7:163. doi: 10.1186/1756-0500-7-163.
To evaluate total antioxidant status (TAS) in the plasma of primary angle closure glaucoma (PACG) patients and to compare it to that of the control group. Additionally, we aim to investigate the association of various PACG clinical indices with TAS level.
Plasma samples were obtained from 139 PACG patients and 149 glaucoma-free controls of matching age, sex, and ethnicity. TAS in all samples was determined by spectrophotometric and enzyme-linked immunosorbent assay methods. We studied the possible association of the TAS level with various clinical indices relevant to PACG.
The mean (±SD) total antioxidant (TAS) value was almost similar in patients 1 (±0.22) compared to controls 0.97 (±0.43); p = 0.345. Among cases, mean TAS concentration showed a statistically significant lower pattern among subjects with glaucoma onset at the age of ≤ 50 years (p = 0.037) and female subjects (p = 0.014) as well as having a family history of glaucoma (p = 0.010). Interestingly, a statistically significant inverse correlation was detected between TAS concentration and intra ocular pressure (IOP), (R = -0.14, p = 0.037).
The inverse correlation of TAS level with IOP, highlights TAS potential role as a predictive-marker for PACG-severity.
评估原发性闭角型青光眼（PACG）患者血浆中的总抗氧化状态（TAS），并与对照组进行比较。此外，我们旨在研究各种PACG临床指标与TAS水平之间的关联。
从139例PACG患者和149例年龄、性别和种族匹配的无青光眼对照者中获取血浆样本。所有样本中的TAS通过分光光度法和酶联免疫吸附测定法进行测定。我们研究了TAS水平与各种与PACG相关的临床指标之间可能的关联。
患者的平均（±标准差）总抗氧化剂（TAS）值为1（±0.22），与对照组的0.97（±0.43）几乎相似；p = 0.345。在病例中，平均TAS浓度在≤50岁发病的青光眼患者（p = 0.037）、女性患者（p = 0.014）以及有青光眼家族史的患者（p = 0.010）中呈现出统计学上显著较低的模式。有趣的是，检测到TAS浓度与眼压（IOP）之间存在统计学上显著的负相关，（R = -0.14，p = 0.037）。
TAS水平与IOP的负相关突出了TAS作为PACG严重程度预测标志物的潜在作用。
