囊性纤维化患者血清中针对铜绿假单胞菌的抗体
Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis.
作者信息
Brett M M, Ghoneim A T, Littlewood J M
出版信息
Arch Dis Child. 1986 Nov;61(11):1114-20. doi: 10.1136/adc.61.11.1114.
Abstract
Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis.
摘要
采用酶联免疫吸附测定法测定血清中针对铜绿假单胞菌细胞表面抗原的IgG抗体。无囊性纤维化患者的抗体滴度较低（140 - 235）。慢性感染铜绿假单胞菌的囊性纤维化患者的抗体滴度非常高（1100 - 20500），而间歇性培养出该菌的患者滴度较低（160 - 4400）。纵向研究表明，在感染的极早期就观察到滴度升高。在慢性和间歇性感染的囊性纤维化患者中，高滴度与临床状态不佳相关，而低滴度与较好的临床状态相关。这些结果表明，该检测是囊性纤维化患者铜绿假单胞菌肺部感染不同阶段严重程度和进展的特异性和敏感性指标。
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