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龙葵果实给药对链脲佐菌素诱导的糖尿病大鼠血糖、血脂水平及肠系膜血管床对去氧肾上腺素敏感性的影响

Effect of the administration of Solanum nigrum fruit on blood glucose, lipid profiles, and sensitivity of the vascular mesenteric bed to phenylephrine in streptozotocin-induced diabetic rats.

作者信息

Sohrabipour Shahla, Kharazmi Fatemah, Soltani Nepton, Kamalinejad Mohammad

机构信息

Department of Physiology, School of Medicine and Research Center for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

Med Sci Monit Basic Res. 2013 Apr 22;19:133-40. doi: 10.12659/MSMBR.883892.

DOI:10.12659/MSMBR.883892
PMID:23660828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3659129/
Abstract

BACKGROUND

Solanum nigrum fruit is traditionally used in Asia to manage, control, and treat diabetes but there is no scientific evidence of the efficacy of Solanum nigrum fruit in treatment of diabetes. We designed this study to investigate the effect of the administration of oral doses of aqueous extract from Solanum nigrum fruit on plasma glucose, lipid profiles, and the sensitivity of the vascular mesenteric bed to Phenylephrine in diabetic and non-diabetic rats.

MATERIAL AND METHODS

Animals were divided into 5 groups (n=10): 2 groups served as non-diabetic controls (NDC), and the other groups had diabetes induced with a single injection of streptozotocin (STZ). Solanum nigrum-treated chronic diabetic (CD-SNE) and Solanum nigrum-treated controls (ND-SNE) received 1g/l of Solanum nigrum added to drinking water for 8 weeks. The mesenteric vascular beds were prepared using the McGregor method.

RESULTS

Administration of Solanum nigrum caused Ca/Mg ratio, plasma glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), total cholesterol, and triglyceride concentrations to return to normal levels, and was shown to decrease alteration in vascular reactivity to vasoconstrictor agents.

CONCLUSIONS

Our results support the hypothesis that Solanum nigrum could play a role in the management of diabetes and the prevention of vascular complications in STZ-induced diabetic rats.

摘要

背景

龙葵果在亚洲传统上用于控制和治疗糖尿病，但尚无科学证据证明龙葵果治疗糖尿病的疗效。我们设计了本研究，以调查口服龙葵果水提取物对糖尿病和非糖尿病大鼠的血糖、血脂谱以及肠系膜血管床对去氧肾上腺素敏感性的影响。

材料与方法

将动物分为5组（n = 10）：2组作为非糖尿病对照组（NDC），其他组通过单次注射链脲佐菌素（STZ）诱导糖尿病。龙葵果治疗的慢性糖尿病组（CD - SNE）和龙葵果治疗的对照组（ND - SNE）在饮水中添加1g/l龙葵果，持续8周。采用麦格雷戈方法制备肠系膜血管床。

结果

给予龙葵果后，钙/镁比值、血糖、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、总胆固醇和甘油三酯浓度恢复至正常水平，并显示出血管对血管收缩剂反应性的改变减少。

结论

我们的结果支持以下假设，即龙葵果在STZ诱导的糖尿病大鼠的糖尿病管理和血管并发症预防中可能发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a948/3659129/b61629d712a2/medscimonitbasicres-19-133-g006.jpg
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