Ceriello Antonio
Internal Medicine, University of Udine, P.le S. Maria della Misericordia, 33100 Udine, Italy.
Diabetes. 2005 Jan;54(1):1-7. doi: 10.2337/diabetes.54.1.1.
Increasing evidence suggests that the postprandial state is a contributing factor to the development of atherosclerosis. In diabetes, the postprandial phase is characterized by a rapid and large increase in blood glucose levels, and the possibility that the postprandial "hyperglycemic spikes" may be relevant to the onset of cardiovascular complications has recently received much attention. Epidemiological studies and preliminary intervention studies have shown that postprandial hyperglycemia is a direct and independent risk factor for cardiovascular disease (CVD). Most of the cardiovascular risk factors are modified in the postprandial phase in diabetic subjects and directly affected by an acute increase of glycemia. The mechanisms through which acute hyperglycemia exerts its effects may be identified in the production of free radicals. This alarmingly suggestive body of evidence for a harmful effect of postprandial hyperglycemia on diabetes complications has been sufficient to influence guidelines from key professional scientific societies. Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes.
越来越多的证据表明，餐后状态是动脉粥样硬化发展的一个促成因素。在糖尿病中，餐后阶段的特征是血糖水平迅速大幅升高，餐后“高血糖峰值”可能与心血管并发症的发生有关这一可能性最近受到了广泛关注。流行病学研究和初步干预研究表明，餐后高血糖是心血管疾病（CVD）的直接和独立危险因素。大多数心血管危险因素在糖尿病患者的餐后阶段会发生改变，并直接受到血糖急性升高的影响。急性高血糖发挥其作用的机制可能与自由基的产生有关。这一令人担忧的证据表明餐后高血糖对糖尿病并发症有有害影响，足以影响主要专业科学协会的指南。纠正餐后高血糖可能是糖尿病心血管疾病预防和管理策略的一部分。
