体液中的甲基化DNA和微小RNA作为癌症检测的生物标志物。
Methylated DNA and microRNA in body fluids as biomarkers for cancer detection.
作者信息
Ma Yanning, Wang Xian, Jin Hongchuan
机构信息
Laboratory of Cancer Biology, Department of Medical Oncology, Institute of Clinical Science, Sir Runrun Shaw Hospital, Medical School of Zhejiang University, Hangzhou 310029, China.
出版信息
Int J Mol Sci. 2013 May 16;14(5):10307-31. doi: 10.3390/ijms140510307.
Abstract
Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
摘要
包括DNA甲基化和微小RNA（miRNA）在内的表观遗传改变在人类癌症的发生和发展中起着重要作用。作为肿瘤中广泛研究的表观遗传变化，DNA甲基化和miRNA是癌症诊断中最具潜力的表观遗传生物标志物。在循环游离核酸被发现后，越来越多的证据表明血液或其他体液中的游离表观遗传生物标志物在癌症检测方面具有巨大潜力。
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