Abe Takashi, Thiebaud Robert S, Loenneke Jeremy P, Loftin Mark, Fukunaga Tetsuo
Department of Health, Exercise Science & Recreation Management, University of Mississippi, 215 Turner Center, Oxford, MS, 38677, USA,
Age (Dordr). 2014 Feb;36(1):417-26. doi: 10.1007/s11357-013-9539-6. Epub 2013 May 18.
The purpose of this study was to compare the prevalence of severe sarcopenia detected by total skeletal muscle mass (SM) index and of site-specific thigh sarcopenia for differing age groups in men and women. Japanese nonobese men and women aged 20 to 85 (n = 1,994, 55 % women) had muscle thickness (MTH) measured by ultrasound at six sites on the anterior and posterior aspects of the body. SM was estimated from ultrasound-derived prediction equations. Site-specific thigh sarcopenia was calculated using ultrasound-measured MTH at the anterior and posterior aspects of the thigh (MTH ratio, anterior 50 %/posterior 50 % thigh MTH (A50/P50 MTH)). Sarcopenia was defined as a SM index (SM divided by height(2)) of >2 standard deviations (SD) below the mean for young adults. Site-specific thigh sarcopenia was defined as a ratio of A50/P50 MTH of >2 SD below the mean for young adults. Age was inversely correlated to SM index and A50/P50 MTH in men (r = -0.480 and r = -0.522) and women (r = -0.243 and r = -0.516). The prevalence rate of sarcopenia was less than 3 % for women under the age of 60, 7 % for ages 60-69, and 24 % for ages 70-80. In men, the prevalence rate of sarcopenia was less than 7 % under the age of 50, 18 % for ages 50-59, 33 % for ages 60-69, and 47 % for ages 70-85. Compared to the sarcopenia estimated by SM index, there was a higher prevalence of site-specific thigh sarcopenia observed in both sexes. These results suggest that site-specific thigh sarcopenia appears before it is able to be detected at the whole body level.
本研究的目的是比较通过总骨骼肌质量（SM）指数检测出的严重肌肉减少症的患病率，以及不同年龄组男性和女性特定部位大腿肌肉减少症的患病率。对年龄在20至85岁的日本非肥胖男性和女性（n = 1994，女性占55%），通过超声测量身体前后六个部位的肌肉厚度（MTH）。根据超声得出的预测方程估算SM。使用超声测量的大腿前后侧MTH（MTH比率，大腿前50%/后50% MTH（A50/P50 MTH））计算特定部位大腿肌肉减少症。肌肉减少症定义为SM指数（SM除以身高²）低于年轻人平均值2个标准差（SD）以上。特定部位大腿肌肉减少症定义为A50/P50 MTH比率低于年轻人平均值2个SD以上。年龄与男性（r = -0.480和r = -0.522）和女性（r = -0.243和r = -0.516）的SM指数及A50/P50 MTH呈负相关。60岁以下女性肌肉减少症患病率低于3%，60 - 69岁为7%，70 - 80岁为24%。男性中，50岁以下肌肉减少症患病率低于7%，50 - 59岁为18%，60 - 69岁为33%，70 - 85岁为47%。与通过SM指数估算的肌肉减少症相比，两性中特定部位大腿肌肉减少症的患病率更高。这些结果表明，特定部位大腿肌肉减少症在全身水平能够被检测到之前就已出现。
