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Of mice and men: what rodent models don't tell us.

作者信息

Drake Adam C

机构信息

Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

出版信息

Cell Mol Immunol. 2013 Jul;10(4):284-5. doi: 10.1038/cmi.2013.21. Epub 2013 May 20.

DOI:10.1038/cmi.2013.21
PMID:23686228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4003210/
Abstract
摘要

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本文引用的文献

1
Genomic responses in mouse models poorly mimic human inflammatory diseases.小鼠模型中的基因组反应与人类炎症性疾病的反应相差很大。
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3507-12. doi: 10.1073/pnas.1222878110. Epub 2013 Feb 11.
2
Humanized mice for immune system investigation: progress, promise and challenges.用于免疫系统研究的人源化小鼠：进展、前景和挑战。
Nat Rev Immunol. 2012 Nov;12(11):786-98. doi: 10.1038/nri3311. Epub 2012 Oct 12.
3
Engineering humanized mice for improved hematopoietic reconstitution.工程化人源化小鼠以改善造血重建。
Cell Mol Immunol. 2012 May;9(3):215-24. doi: 10.1038/cmi.2012.6. Epub 2012 Mar 19.
4
Drug for severe sepsis is withdrawn from market, fails to reduce mortality.用于严重脓毒症的药物退出市场，未能降低死亡率。
JAMA. 2011 Dec 14;306(22):2439-40. doi: 10.1001/jama.2011.1755.
5
Current insights in sepsis: from pathogenesis to new treatment targets.脓毒症的最新研究进展：从发病机制到新的治疗靶点。
Curr Opin Crit Care. 2011 Oct;17(5):480-6. doi: 10.1097/MCC.0b013e32834a4aeb.
6
Can animal models of disease reliably inform human studies?疾病的动物模型能可靠地为人类研究提供信息吗？
PLoS Med. 2010 Mar 30;7(3):e1000245. doi: 10.1371/journal.pmed.1000245.
7
Initial sequencing and comparative analysis of the mouse genome.小鼠基因组的初步测序与比较分析。
Nature. 2002 Dec 5;420(6915):520-62. doi: 10.1038/nature01262.