Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Jülich Aachen Research Alliance (JARA) - Translational Brain Medicine, Aachen, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Institute of Neuroscience and Medicine (INM-1, INM-2), Research Center Jülich, Jülich, Germany; Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Neuroimage. 2013 Nov 1;81:381-392. doi: 10.1016/j.neuroimage.2013.05.046. Epub 2013 May 17.
The right temporo-parietal junction (RTPJ) is consistently implicated in two cognitive domains, attention and social cognitions. We conducted multi-modal connectivity-based parcellation to investigate potentially separate functional modules within RTPJ implementing this cognitive dualism. Both task-constrained meta-analytic coactivation mapping and task-free resting-state connectivity analysis independently identified two distinct clusters within RTPJ, subsequently characterized by network mapping and functional forward/reverse inference. Coactivation mapping and resting-state correlations revealed that the anterior cluster increased neural activity concomitantly with a midcingulate-motor-insular network, functionally associated with attention, and decreased neural activity concomitantly with a parietal network, functionally associated with social cognition and memory retrieval. The posterior cluster showed the exact opposite association pattern. Our data thus suggest that RTPJ links two antagonistic brain networks processing external versus internal information.
右侧颞顶联合区（RTPJ）一直与注意力和社会认知两个认知领域有关。我们进行了基于多模态连接的分区，以研究在实现这种认知二元论的情况下，RTPJ 内可能存在的分离功能模块。任务约束的元分析共激活映射和任务自由的静息状态连接分析独立地在 RTPJ 内确定了两个不同的簇，随后通过网络映射和功能前向/反向推理进行了特征描述。共激活映射和静息状态相关性表明，前簇与中扣带回-运动-岛网络的神经活动同时增加，与注意力功能相关，与社会认知和记忆检索功能相关的顶叶网络的神经活动同时减少。后簇显示出完全相反的关联模式。因此，我们的数据表明，RTPJ 将两个处理外部与内部信息的拮抗脑网络连接起来。
