Khodabandehloo Fatimeh, Hosseini Mahmoud, Rajaei Ziba, Soukhtanloo Mohammad, Farrokhi Esmaeil, Rezaeipour Mohsen
Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Arq Neuropsiquiatr. 2013 May;71(5):313-9. doi: 10.1590/0004-282x20130027.
In addition to antioxidative effects, estrogens also exert pro-oxidative actions. The effect of chronic administration of a high dose of estradiol valerate on Morris water maze tasks and brain tissues oxidative damage was investigated. The Sham-Est and OVX-Est groups were treated with estradiol valerate (4 mg/kg) for 12 weeks. Escape latency and traveled path in the Sham-Est and OVX-Est groups were significantly higher than in the Sham and OVX groups (p<0.01 and p<0.001). In the probe trial, the animals of the Sham-Est and OVX-Est groups spent lower time in Q1 compared to Sham and OVX groups (p<0.05 and p<0.001). In Sham-Est and OVX-Est groups, the brain tissue total thiol concentration was significantly lower, and malondialdehyde (MDA) concentrations were higher than in the Sham and OVX groups (p<0.05 and p<0.001). It is concluded that administration of high exogenous levels of estradiol impairs performance and enhances oxidative stress.
除了抗氧化作用外，雌激素还具有促氧化作用。研究了长期高剂量戊酸雌二醇给药对莫里斯水迷宫任务和脑组织氧化损伤的影响。假手术-雌激素组和去卵巢-雌激素组用戊酸雌二醇（4mg/kg）治疗12周。假手术-雌激素组和去卵巢-雌激素组的逃避潜伏期和游动路径显著高于假手术组和去卵巢组（p<0.01和p<0.001）。在探索性实验中，假手术-雌激素组和去卵巢-雌激素组的动物在第一象限停留的时间比假手术组和去卵巢组短（p<0.05和p<0.001）。假手术-雌激素组和去卵巢-雌激素组的脑组织总硫醇浓度显著降低，丙二醛（MDA）浓度高于假手术组和去卵巢组（p<0.05和p<0.001）。结论是，高剂量外源性雌激素给药会损害行为表现并增强氧化应激。
