State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China.
Dalton Trans. 2013 Jul 21;42(27):9877-83. doi: 10.1039/c3dt50243k. Epub 2013 May 21.
A new type of organophosphonic acid, (4,4'-(1,2-diphenylethene-1,2-diyl)bis(4,1-phenylene))bis(methylene)diphosphonic acid (PATPE), based on tetraphenylethene has been prepared, and its ester derivative exhibits the characteristic property of aggregation-induced emission (AIE) in DMSO-H2O solution. The PATPE is then fabricated into hydroxyapatite by a one-pot condensation process to form hollow mesoporous nanocapsules of ellipsoidal morphology. The AIE luminogen-bridged hollow hydroxyapatite nanocapsules emit strong blue light under UV irradiation, which is further used for drug delivery using ibuprofen (IBU) as a model drug. The fluorescence intensity of the materials varies greatly with the loading and release of IBU, suggesting that the drug release process may be tracked in terms of the change of luminescence intensity. The biocompatibility of AIE luminogen functionalized material is also evaluated on HUH7 human hepatoma cells using the MTT assay. The low cytotoxicity of the materials reveals that the as-prepared multifunctional hydroxyapatite will be a new candidate for simultaneous drug delivery and cell imaging in potential bioapplications.
一种新型的有机膦酸，（4,4'-(1,2-二苯基乙烯-1,2-二基)双(4,1-亚苯基))双(亚甲基)二膦酸(PATPE)，基于四苯乙烯已经被制备出来，并且它的酯衍生物在 DMSO-H2O 溶液中表现出聚集诱导发射(AIE)的特征性质。然后，PATPE 通过一锅缩合过程被制成羟基磷灰石，形成具有椭圆形形态的中空介孔纳米胶囊。在 UV 照射下，AIE 发光体桥连的中空羟基磷灰石纳米胶囊发出强蓝光，进一步将其用作布洛芬(IBU)作为模型药物的药物传递。材料的荧光强度随 IBU 的加载和释放而发生很大变化，这表明药物释放过程可以根据发光强度的变化来进行跟踪。还使用 MTT 测定法在 HUH7 人肝癌细胞上评估了 AIE 发光体功能化材料的生物相容性。材料的低细胞毒性表明，所制备的多功能羟基磷灰石将成为潜在生物应用中同时进行药物输送和细胞成像的新候选物。
