Department of Occupational & environmental Health, Faculty of Medical Sciences, Tarbiat Modares University, North Kargar Street, Tehran, Iran.
J Environ Public Health. 2013;2013:150693. doi: 10.1155/2013/150693. Epub 2013 Apr 14.
Shift work is associated with sleep deprivation, occupational stress, and increased risk of depression. Depressed patients show increased oxidative stress. During excessive oxidative stress, Malondialdehyde (MDA) increases and total antioxidant capacity (TAC) decreases in body. This cross-sectional study was conducted to determine the serum level of TAC and MDA among depressed rotational shift workers in Shahid Tondooyan Tehran Oil Refinery. 21-item Beck Depression Inventory was used to measure depression level. The level of TAC and MDA was measured by 8 mL fasting blood sample. MDA was determined by thiobarbituric acid reaction. Serum total antioxidants were measured using the ABTS. Results of this study showed that TAC mean and standard deviation concentration was 2.451 (±0.536) mg/dL and MDA was 3.725 (±1.098) mic·mol/L, and mean and standard deviation of depression score and BMI were 14.07 (±3.84) and 24.92 (±3.65) kg/m(2), respectively. Depression score had a positive correlation with rotational shift work experience and work experience (r = 0.218 and r = 0.212), respectively, (P < 0.05).
轮班工作与睡眠剥夺、职业压力和抑郁风险增加有关。抑郁患者表现出氧化应激增加。在过度氧化应激下，体内丙二醛（MDA）增加，总抗氧化能力（TAC）减少。本横断面研究旨在确定德黑兰沙希德通迪扬炼油厂抑郁轮班工人的血清 TAC 和 MDA 水平。使用 21 项贝克抑郁量表来衡量抑郁程度。TAC 和 MDA 水平通过 8 毫升空腹血样测定。通过硫代巴比妥酸反应测定 MDA。使用 ABTS 测量血清总抗氧化剂。本研究结果表明，TAC 平均值和标准差浓度分别为 2.451（±0.536）mg/dL 和 MDA 为 3.725（±1.098）μmol/L，抑郁评分和 BMI 的平均值和标准差分别为 14.07（±3.84）和 24.92（±3.65）kg/m2。抑郁评分与轮班工作经验和工作经验呈正相关（r = 0.218 和 r = 0.212）（P < 0.05）。
