古德综合征，一名中国患者胸腺切除术后难治性慢性腹泻和反复肺炎的罕见病因。
Good Syndrome, a rare cause of refractory chronic diarrhea and recurrent pneumonia in a Chinese patient after thymectomy.
作者信息
Qu Junyan, Lü Xiaoju, Gao Qin, Zhang Yan
机构信息
Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Clin Vaccine Immunol. 2013 Jul;20(7):1097-8. doi: 10.1128/CVI.00141-13. Epub 2013 May 22.
Abstract
The diagnosis of Good syndrome is very difficult. It has various symptoms, and these symptoms can be present at different periods. In this report we present a patient with refractory chronic diarrhea, recurrent pneumonia, and dysgammaglobulinemia after thymectomy, who was finally then diagnosed with Good syndrome.
摘要
古德综合征的诊断非常困难。它有多种症状，且这些症状可出现在不同时期。在本报告中，我们介绍了一名患者，该患者在胸腺切除术后出现难治性慢性腹泻、复发性肺炎和免疫球蛋白异常血症，最终被诊断为古德综合征。
相似文献
1
Good Syndrome, a rare cause of refractory chronic diarrhea and recurrent pneumonia in a Chinese patient after thymectomy.古德综合征，一名中国患者胸腺切除术后难治性慢性腹泻和反复肺炎的罕见病因。
Clin Vaccine Immunol. 2013 Jul;20(7):1097-8. doi: 10.1128/CVI.00141-13. Epub 2013 May 22.
2
A rare combination of recurrent pneumonia, diarrhoea, and visual loss in a patient after thymectomy: good syndrome.一位胸腺瘤切除术后患者出现反复肺炎、腹泻和视力丧失：Good 综合征。
Hong Kong Med J. 2010 Dec;16(6):493-6.
3
[Intestinal lymphoid nodular hyperplasia in a patient with acquired dysgammaglobulinemia, chronic diarrhea, and bacterial overgrowth syndrome].[一名患有获得性γ球蛋白异常血症、慢性腹泻和细菌过度生长综合征患者的肠道淋巴样结节增生]
Rev Gastroenterol Mex. 1993 Jul-Sep;58(3):225-8.
4
IgA deficiency, recurrent pneumonias, and bronchiectasis.IgA 缺乏症、复发性肺炎和支气管扩张症。
Chest. 1978 Apr;73(4):519-26. doi: 10.1378/chest.73.4.519.
5
A familial case of hyper-IgM immunodeficiency.一例家族性高IgM免疫缺陷病例。
Acta Haematol. 1992;88(1):50-4. doi: 10.1159/000204596.
6
Recurrent neutropenia and chronic diarrhea following thymectomy: the good, the bad, and the ugly.胸腺切除术后复发性中性粒细胞减少和慢性腹泻：有利、有弊、有风险。
J Community Hosp Intern Med Perspect. 2021 Mar 23;11(2):263-265. doi: 10.1080/20009666.2021.1877400.
7
[Secretory Ig-A deficiency in a patient with diffuse panbronchiolitis, atrophic gastritis, and hypokalemic myopathy following diarrhea].[一名患有弥漫性泛细支气管炎、萎缩性胃炎及腹泻后低钾性肌病患者的分泌型Ig-A缺乏症]
Nihon Naika Gakkai Zasshi. 1986 Jul;75(7):946-50. doi: 10.2169/naika.75.946.
8
Chronic diarrhea and pneumonia.慢性腹泻和肺炎。
Ann Allergy Asthma Immunol. 1997 Apr;78(4):339-44. doi: 10.1016/S1081-1206(10)63193-6.
9
IgG immunodeficiency in a half-Arabian foal with salmonellosis.一匹患有沙门氏菌病的半阿拉伯马驹的IgG免疫缺陷。
Vet Med Small Anim Clin. 1981 Feb;76(2):231-4.
10
Severe diarrhea due to Isospora belli in a patient with thymoma.因胸腺肿瘤导致的比氏肠孢子虫引起的严重腹泻。
J Microbiol Immunol Infect. 2009 Dec;42(6):526-9.
引用本文的文献
1
Gastrointestinal pathology in Good's syndrome, thinking beyond common variable immunodeficiency: a clinicopathological observation.古德综合征中的胃肠道病理学：超越常见可变免疫缺陷的思考——一项临床病理观察
Virchows Arch. 2025 Mar 26. doi: 10.1007/s00428-025-04069-7.
2
Good's syndrome combined with CMV gastroenteritis: A case report and literature review.古德综合征合并巨细胞病毒胃肠炎：一例报告及文献复习
Clin Case Rep. 2024 Jun 14;12(6):e9024. doi: 10.1002/ccr3.9024. eCollection 2024 Jun.
3
When the Good Syndrome Goes Bad: A Systematic Literature Review.当“好综合征”变得糟糕：系统文献回顾。
Front Immunol. 2021 May 25;12:679556. doi: 10.3389/fimmu.2021.679556. eCollection 2021.
4
Recurrent neutropenia and chronic diarrhea following thymectomy: the good, the bad, and the ugly.胸腺切除术后复发性中性粒细胞减少和慢性腹泻：有利、有弊、有风险。
J Community Hosp Intern Med Perspect. 2021 Mar 23;11(2):263-265. doi: 10.1080/20009666.2021.1877400.
5
Atypical presentation of Good syndrome: acute hepatitis from hepatitis B virus reactivation.古德综合征的非典型表现：乙型肝炎病毒再激活所致急性肝炎
Asia Pac Allergy. 2020 Oct 20;10(4):e37. doi: 10.5415/apallergy.2020.10.e37. eCollection 2020 Oct.
6
A Rare Case of Colonic Sarcoidosis Presenting as a Mass.一例罕见的以肿块形式表现的结肠结节病
Case Rep Gastrointest Med. 2020 Oct 10;2020:8882863. doi: 10.1155/2020/8882863. eCollection 2020.
7
Thymic epithelial tumor complicated by immunological abnormalities: results from a single-center retrospective study in China.胸腺上皮肿瘤合并免疫异常：来自中国一项单中心回顾性研究的结果
J Thorac Dis. 2019 Apr;11(4):1580-1588. doi: 10.21037/jtd.2019.02.90.
8
A Good Case of Recurrent Pneumonia.复发性肺炎的一个典型病例
J Investig Med High Impact Case Rep. 2018 Sep 29;6:2324709618802869. doi: 10.1177/2324709618802869. eCollection 2018 Jan-Dec.
9
Good's Syndrome Patients Hospitalized for Infections: A Single-Center Retrospective Study.因感染住院的古德综合征患者：一项单中心回顾性研究。
Medicine (Baltimore). 2015 Nov;94(47):e2090. doi: 10.1097/MD.0000000000002090.
本文引用的文献
1
Chronic diarrhea and malabsorption due to hypogammaglobulinemia: a report on twelve patients.低丙种球蛋白血症所致慢性腹泻和吸收不良：12例患者报告
Indian J Gastroenterol. 2011 Jul;30(4):170-4. doi: 10.1007/s12664-011-0111-y. Epub 2011 Jul 23.
2
Persistence of immunological alterations after thymectomy in Good's syndrome: a clue to its pathogenesis.Good 综合征胸腺切除术后免疫改变的持续存在：其发病机制的一个线索。
Cytometry B Clin Cytom. 2011 Sep;80(5):339-42. doi: 10.1002/cyto.b.20595. Epub 2011 Apr 25.
3
A rare combination of recurrent pneumonia, diarrhoea, and visual loss in a patient after thymectomy: good syndrome.一位胸腺瘤切除术后患者出现反复肺炎、腹泻和视力丧失：Good 综合征。
Hong Kong Med J. 2010 Dec;16(6):493-6.
4
Good's syndrome remains a mystery after 55 years: A systematic review of the scientific evidence.Good 综合征 55 年后仍是未解之谜：系统综述科学证据。
Clin Immunol. 2010 Jun;135(3):347-63. doi: 10.1016/j.clim.2010.01.006. Epub 2010 Feb 10.
5
Dementia in a patient with Thymoma and hypogammaglobulinaemia (Good's syndrome).胸腺瘤合并低丙种球蛋白血症（古德综合征）患者的痴呆症
Cases J. 2008 Aug 13;1(1):90. doi: 10.1186/1757-1626-1-90.
6
Good syndrome coexisting with leukopenia.古德综合征合并白细胞减少症。
Ann Thorac Surg. 2007 Dec;84(6):2095-7. doi: 10.1016/j.athoracsur.2007.06.070.
7
Thymoma with chronic diarrhea: report of two cases and review of the literature.胸腺瘤伴慢性腹泻：两例报告并文献复习
Med Oncol. 2007;24(1):119-23. doi: 10.1007/BF02685913.
8
Thymoma and immunodeficiency (Good syndrome): a report of 2 unusual cases and review of the literature.胸腺瘤与免疫缺陷（古德综合征）：2例罕见病例报告及文献复习
Ann Allergy Asthma Immunol. 2007 Feb;98(2):185-90. doi: 10.1016/S1081-1206(10)60695-3.
9
Regulatory T cells in the establishment and maintenance of self-tolerance: role of the thymic epithelium.调节性T细胞在自身耐受的建立和维持中的作用：胸腺上皮的作用
Int J Dev Biol. 2005;49(2-3):137-42. doi: 10.1387/ijdb.041959js.
10
Good's syndrome: an unusual cause of chronic diarrhea.古德综合征：慢性腹泻的一种罕见病因。
Indian J Gastroenterol. 2004 Jul-Aug;23(4):152-3.
Zotero 插件