表达北美系 H7 亚型血凝素的重组新城疫病毒诱导针对新型 H7N9 流感病毒的交叉反应性抗体。
Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.
机构信息
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
出版信息
J Virol. 2013 Jul;87(14):8235-40. doi: 10.1128/JVI.01085-13. Epub 2013 May 22.
Abstract
Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.
摘要
中国出现的新型 H7N9 流感病毒引发了严重的人类疾病，需要迅速做出反应。在此，我们介绍了一种表达北美的 H7 流感病毒血凝素的重组新城疫病毒。免疫小鼠的血清与多种 H7 亚型病毒发生交叉反应，并抑制新型 H7 血凝素的血凝作用。免疫小鼠可抵抗异源 H7 亚型的攻击，遗传分析表明，交叉保护抗体识别保守的抗原表位。
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