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本文引用的文献

1
Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, February to April 2013.2013 年 2 月至 4 月期间从中国患者中分离出的新型甲型 H7N9 流感病毒的基因分析。
Euro Surveill. 2013 Apr 11;18(15):20453.
2
Human infection with a novel avian-origin influenza A (H7N9) virus.人感染新型甲型 H7N9 流感病毒。
N Engl J Med. 2013 May 16;368(20):1888-97. doi: 10.1056/NEJMoa1304459. Epub 2013 Apr 11.
3
Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies.嵌合血凝素流感病毒疫苗构建体引发广泛保护性茎特异性抗体。
J Virol. 2013 Jun;87(12):6542-50. doi: 10.1128/JVI.00641-13. Epub 2013 Apr 10.
4
Emergence of influenza viruses with zoonotic potential: open issues which need to be addressed. A review.具有人畜共患潜力的流感病毒的出现：需要解决的未决问题。综述。
Vet Microbiol. 2013 Jul 26;165(1-2):7-12. doi: 10.1016/j.vetmic.2013.01.044. Epub 2013 Feb 8.
5
Connecting the study of wild influenza with the potential for pandemic disease.将野生流感的研究与潜在的大流行病联系起来。
Infect Genet Evol. 2013 Jul;17:162-87. doi: 10.1016/j.meegid.2013.02.020. Epub 2013 Mar 26.
6
Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.与人类结膜炎相关的高致病性禽流感 A（H7N3）病毒的发病机制、传染性和眼倾向性。
J Virol. 2013 May;87(10):5746-54. doi: 10.1128/JVI.00154-13. Epub 2013 Mar 13.
7
H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice.H3N2 流感病毒感染可诱导人和小鼠产生广泛反应性的血凝素茎部抗体。
J Virol. 2013 Apr;87(8):4728-37. doi: 10.1128/JVI.03509-12. Epub 2013 Feb 13.
8
Residual baculovirus in insect cell-derived influenza virus-like particle preparations enhances immunogenicity.昆虫细胞来源的流感病毒样颗粒制剂中的残留杆状病毒增强了免疫原性。
PLoS One. 2012;7(12):e51559. doi: 10.1371/journal.pone.0051559. Epub 2012 Dec 7.
9
A carboxy-terminal trimerization domain stabilizes conformational epitopes on the stalk domain of soluble recombinant hemagglutinin substrates.羧基末端三聚化结构域稳定可溶性重组血凝素底物茎部结构域上的构象表位。
PLoS One. 2012;7(8):e43603. doi: 10.1371/journal.pone.0043603. Epub 2012 Aug 23.
10
A majority of infectious Newcastle disease virus particles contain a single genome, while a minority contain multiple genomes.大多数传染性 Newcastle 疾病病毒颗粒含有单个基因组，而少数含有多个基因组。
J Virol. 2012 Oct;86(19):10852-6. doi: 10.1128/JVI.01298-12. Epub 2012 Jul 11.

表达北美系 H7 亚型血凝素的重组新城疫病毒诱导针对新型 H7N9 流感病毒的交叉反应性抗体。

Induction of cross-reactive antibodies to novel H7N9 influenza virus by recombinant Newcastle disease virus expressing a North American lineage H7 subtype hemagglutinin.

机构信息

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出版信息

J Virol. 2013 Jul;87(14):8235-40. doi: 10.1128/JVI.01085-13. Epub 2013 May 22.

DOI:10.1128/JVI.01085-13
PMID:23698299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3700175/
Abstract

Severe human disease caused by the emerging H7N9 influenza virus in China warrants a rapid response. Here, we present a recombinant Newcastle disease virus expressing a North American lineage H7 influenza virus hemagglutinin. Sera from immunized mice were cross-reactive to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin. Immunized mice were protected against a heterologous H7 subtype challenge, and genetic analysis suggested that cross-protective antibodies recognize conserved antigenic sites.

摘要

中国出现的新型 H7N9 流感病毒引发了严重的人类疾病，需要迅速做出反应。在此，我们介绍了一种表达北美的 H7 流感病毒血凝素的重组新城疫病毒。免疫小鼠的血清与多种 H7 亚型病毒发生交叉反应，并抑制新型 H7 血凝素的血凝作用。免疫小鼠可抵抗异源 H7 亚型的攻击，遗传分析表明，交叉保护抗体识别保守的抗原表位。