Siwach S B, Kalra O P, Sharma R, Singh V, Chopra J S
Department of Medicine, Medical College Hospital, Rohtak.
Indian J Med Res. 1990 Apr;92:105-8.
The product of protein/creatinine ratio (in a random urine specimen) and estimated daily urinary creatinine excretion were evaluated as a function of 24 h urinary protein excretion in 40 patients with pathology proteinuria having varying grades of renal function. An excellent correlation was found between the results obtained by this method and those from the standard 24 h urine collection method in healthy controls (r = 0.99) and in patients with normal (r = 0.88) or mild to moderately impaired renal function (r = 0.99). However, this method did not give a good measure of quantitative proteinuria in patients with advanced renal failure (r = 0.56), possibly due to decreased urinary excretion of creatinine in patients with advanced renal failure as compared to the estimated value. The product of protein/creatinine ratio and estimated daily urinary creatinine excretion thus gave a quick and alternate reliable method of estimating 24 h proteinuria in patients having normal or mild to moderately impaired renal function. However, this method is not suitable for patients with advanced renal failure.
对40例患有不同程度肾功能损害的病理性蛋白尿患者，评估了（随机尿标本中的）蛋白质/肌酐比值与估计的每日尿肌酐排泄量的乘积作为24小时尿蛋白排泄量的函数。在健康对照者（r = 0.99）以及肾功能正常（r = 0.88）或轻度至中度受损的患者（r = 0.99）中，通过该方法获得的结果与标准24小时尿液收集方法的结果之间发现了极好的相关性。然而，该方法对于晚期肾衰竭患者的定量蛋白尿测量效果不佳（r = 0.56），这可能是由于晚期肾衰竭患者的尿肌酐排泄量与估计值相比有所降低。因此，蛋白质/肌酐比值与估计的每日尿肌酐排泄量的乘积为评估肾功能正常或轻度至中度受损患者的24小时蛋白尿提供了一种快速且可靠的替代方法。然而，该方法不适用于晚期肾衰竭患者。
