Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California San Francisco, 505 Parnassus Avenue, Box 0130, San Francisco, CA, 94143-0130, USA,
Curr Allergy Asthma Rep. 2013 Oct;13(5):453-61. doi: 10.1007/s11882-013-0355-y.
Recent applications of culture-independent tools for microbiome profiling have revealed significant relationships between asthma and microbiota associated with the environment, gut, or airways. Studies of the airway microbiome in particular represent a new frontier in pulmonary research. Although these studies are relatively new, current evidence suggests the possibility of new therapeutic strategies for the treatment or prevention of asthma. In this article, recent literature on microbiota and asthma are critically reviewed, with a particular focus on studies of the airway microbiome. Perspectives are presented on how growing knowledge of relationships between the microbiome and asthma is likely to translate into improved understanding of asthma pathogenesis, its heterogeneity, and opportunities for novel treatment approaches.
最近，非培养工具在微生物组分析中的应用揭示了哮喘与环境、肠道或气道相关的微生物群之间的显著关系。特别是气道微生物组的研究代表了肺部研究的一个新领域。尽管这些研究相对较新，但目前的证据表明，可能有新的治疗策略可用于治疗或预防哮喘。本文批判性地回顾了关于微生物组和哮喘的最新文献，特别关注气道微生物组的研究。本文还提出了这样一种观点，即对微生物组和哮喘之间关系的认识不断增加，很可能会促进对哮喘发病机制、异质性以及新型治疗方法的机会的深入理解。
