Lv Hailong, Li Siyuan, Zhang Jing, Liang Weihua, Mu Xiaoling, Jiang Yufeng
Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang, China.
Korean J Parasitol. 2013 Apr;51(2):255-8. doi: 10.3347/kjp.2013.51.2.255. Epub 2013 Apr 25.
Spillage of cyst contents during surgical operation is the major cause of recurrence after hydatid cyst surgery. Instillation of a scolicidal agent into a hepatic hydatid cyst is the most commonly employed measure to prevent this complication. SB202190 is a pyridinyl imidazole derivative and is known to be a specific inhibitor of p38 MAPK. In the present study, the scolicidal effect of SB202190 was investigated. Freshly isolated Echinococcus granulosus protoscolices were subjected to SB202190 treatment (10, 20, 40, and 80 µM), and the effects on parasite viability were monitored by trypan blue staining. Corresponding effects were visualized by scanning and transmission electron microscopy. Dose-dependent protoscolex death within a few days of SB202190 treatment was observed. Although the in vitro scolicidal effect of SB202190 was satisfactory, the in vivo efficacy of this drug and also possible side effects remain to be further investigated.
手术过程中囊内容物的溢出是包虫囊肿手术后复发的主要原因。向肝包虫囊肿内注入杀头节剂是预防该并发症最常用的措施。SB202190是一种吡啶基咪唑衍生物，已知是p38丝裂原活化蛋白激酶的特异性抑制剂。在本研究中，研究了SB202190的杀头节作用。将新鲜分离的细粒棘球绦虫原头节用SB202190（10、20、40和80 μM）处理，并用台盼蓝染色监测对寄生虫活力的影响。通过扫描电子显微镜和透射电子显微镜观察相应的效果。观察到在SB202190处理后的几天内原头节呈剂量依赖性死亡。尽管SB202190的体外杀头节效果令人满意，但该药物的体内疗效以及可能的副作用仍有待进一步研究。
