Zibaei Mohammad, Sarlak Amanallah, Delfan Bahram, Ezatpour Behrouz, Azargoon Alireza
Division of Parasitology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorram Abad, Iran.
Korean J Parasitol. 2012 Mar;50(1):53-6. doi: 10.3347/kjp.2012.50.1.53. Epub 2012 Mar 6.
Treatment of hydatid disease is mainly surgical, with medical treatment being reserved as a coadjuvant treatment. Use of effective scolicidal agents during surgery of cystic echinococcosis is essential to reduce the recurrence rate. The goal of this study was to evaluate the in vitro scolicidal effects of hydroalcoholic extracts of Satureja khuzestanica leaves and aqueous extracts of Olea europaea leaves on hydatid cyst protoscolices. Echinococcus granulosus protoscolices were collected from the liver of sheep infected with the hydatid cyst. Various concentrations of plant extracts were used in different exposure times for viability assay of protoscolices. Among the olive leaf extracts tested, 0.1% and 0.01% concentrations had strong scolicidal effects in 120 min. S. khuzestanica 0.1% had very strong scolicidal effects in 30, 60, and 120 min of exposure times and the mortality rate decreased with the lower concentration. The finding have shown that the scolicidal activity of S. khuzestanica against cystic echinococosis protoscolices were more effective, while the O. europaea extract showed less effects.
包虫病的治疗主要是手术治疗，药物治疗作为辅助治疗手段。在囊性棘球蚴病手术中使用有效的杀头节剂对于降低复发率至关重要。本研究的目的是评估胡齐斯坦风轮菜叶片水醇提取物和油橄榄叶水提取物对包虫囊肿原头节的体外杀头节作用。从感染包虫囊肿的绵羊肝脏中收集细粒棘球绦虫原头节。使用不同浓度的植物提取物在不同暴露时间对原头节进行活力测定。在所测试的橄榄叶提取物中，0.1%和0.01%的浓度在120分钟内具有较强的杀头节作用。0.1%的胡齐斯坦风轮菜在暴露30、60和120分钟时具有很强的杀头节作用，且随着浓度降低死亡率下降。研究结果表明，胡齐斯坦风轮菜对囊性棘球蚴病原头节的杀头节活性更有效，而油橄榄叶提取物的效果较差。
