Admani Shehla, Krakowski Andrew C
Drs. Admani and Krakowski are from the University of California, San Diego, La Jolla, California, and Rady Children's Hospital, San Diego, California.
J Clin Aesthet Dermatol. 2013 May;6(5):19-23.
Neonatal lupus erythematosus is a rare autoimmune disease caused by transplacental passage of maternal autoantibodies against Ro/SS-A, La/SS-B, and U1-ribonucleoprotein. The clinical spectrum of neonatal lupus erythematosus comprises cutaneous, cardiac, and systemic abnormalities. Typical cutaneous manifestations include annular erythematous plaques with or without fine scale predominately on the scalp, neck, or face and less commonly on the trunk and extremities. The authors describe the case of a two-month-old male child who developed atypical, targetoid-like lesions involving the genitals and soles of the feet after brief sun exposure and was subsequently diagnosed with neonatal lupus erythematosus.
新生儿红斑狼疮是一种罕见的自身免疫性疾病，由母体抗Ro/SS-A、La/SS-B和U1核糖核蛋白自身抗体经胎盘传递引起。新生儿红斑狼疮的临床谱包括皮肤、心脏和全身异常。典型的皮肤表现为环形红斑斑块，有或无细小鳞屑，主要出现在头皮、颈部或面部，较少见于躯干和四肢。作者描述了一名两个月大男童的病例，该患儿在短暂日晒后出现累及生殖器和脚底的非典型靶样病变，随后被诊断为新生儿红斑狼疮。
