Genomics and Health, Center for Public Health Research (CSISP), 46020 Valencia, Spain.
Trends Microbiol. 2010 Oct;18(10):432-8. doi: 10.1016/j.tim.2010.07.008. Epub 2010 Aug 24.
A significant fraction of human cancers is associated with infections by different papillomaviruses (PVs). In other vertebrates, the presence of specific PVs is also associated with different neoplasias. The popular view of PVs conceives them to be largely static and relies on generalized assumptions that have rarely been rigorously tested such as: virus-host codivergence, strict tissue tropism and host-specificity, their very low mutation rate and the absence of recombination. Here, we want to stress the need and the medical importance of understanding the evolutionary history and present-day dynamics of PVs. Understanding the way that PV genomes have evolved will clarify the link between a given genotype and the phenotypic and clinical outcome of the corresponding viral infection.
相当一部分人类癌症与不同的乳头瘤病毒（PVs）感染有关。在其他脊椎动物中，特定的 PVs 的存在也与不同的肿瘤有关。人们普遍认为 PVs 基本上是静态的，并依赖于很少经过严格检验的一般性假设，例如：病毒-宿主共进化、严格的组织嗜性和宿主特异性、极低的突变率以及没有重组。在这里，我们要强调理解 PV 进化历史和当今动态的必要性和医学重要性。了解 PV 基因组的进化方式将阐明特定基因型与相应病毒感染的表型和临床结果之间的联系。
