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Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains.

作者信息

Vanhoof R, Hubrechts J M, Nyssen H J, Nulens E, Leger J, de Schepper N, Kupperberg E, Couvreur M L

机构信息

Unit of Antibiotic Research, Institute Pasteur of Brabant, Brussels, Belgium.

出版信息

Pharm Weekbl Sci. 1990 Jun 22;12(3):104-6. doi: 10.1007/BF01967603.

DOI:10.1007/BF01967603
PMID:2371139
Abstract

By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration greater than or equal to 8 mg/l) or resistant (minimal inhibiting concentration greater than or equal to 64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam-mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations.

摘要

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本文引用的文献

1
Synergistic combinations of antibiotics in gram-negative bacillary infections.革兰氏阴性杆菌感染中抗生素的协同组合
Rev Infect Dis. 1982 Mar-Apr;4(2):294-301. doi: 10.1093/clinids/4.2.294.
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In vitro antagonism of beta-lactam antibiotics by cefoxitin.头孢西丁对β-内酰胺类抗生素的体外拮抗作用。
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Antagonism of carbenicillin and cefamandole by cefoxitin in treatment of experimental infections in mice.头孢西丁对羧苄青霉素和头孢孟多在小鼠实验性感染治疗中的拮抗作用
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Antimicrobial effect of beta-lactam antibiotic combinations against Bacteroides fragilis in vitro.β-内酰胺类抗生素组合对脆弱拟杆菌的体外抗菌作用。
Antimicrob Agents Chemother. 1983 Jan;23(1):166-8. doi: 10.1128/AAC.23.1.166.
5
Comparative in vitro synergistic activity of new beta-lactam antimicrobial agents and amikacin against Pseudomonas aeruginosa and Serratia marcescens.新型β-内酰胺类抗菌剂与阿米卡星对铜绿假单胞菌和粘质沙雷氏菌的体外协同活性比较
Antimicrob Agents Chemother. 1981 Aug;20(2):239-43. doi: 10.1128/AAC.20.2.239.
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Studies of in vitro synergy between several beta-lactam and aminoglycoside antibiotics against endocarditis strains of Pseudomonas aeruginosa.几种β-内酰胺类抗生素与氨基糖苷类抗生素对铜绿假单胞菌心内膜炎菌株的体外协同作用研究。
J Infect. 1984 Mar;8(2):110-7. doi: 10.1016/s0163-4453(84)92385-5.
7
In vitro activity of aztreonam in combination with newer beta-lactams and amikacin against multiply resistant gram-negative bacilli.氨曲南与新型β-内酰胺类抗生素及阿米卡星联合应用对多重耐药革兰阴性杆菌的体外活性
Antimicrob Agents Chemother. 1984 Feb;25(2):283-5. doi: 10.1128/AAC.25.2.283.
8
Early synergistic interactions between amikacin and six beta-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae.阿米卡星与六种β-内酰胺类抗生素对多重耐药肠杆菌科细菌的早期协同相互作用。
Antimicrob Agents Chemother. 1984 Sep;26(3):378-81. doi: 10.1128/AAC.26.3.378.
9
In vitro and in vivo antibacterial effects of combinations of beta-lactam antibiotics.β-内酰胺类抗生素组合的体外和体内抗菌作用
Antimicrob Agents Chemother. 1981 Apr;19(4):634-8. doi: 10.1128/AAC.19.4.634.
10
Comparative synergistic activity of cefoperazone, cefotaxime, moxalactam, and carbenicillin, combined with tobramycin, against Pseudomonas aeruginosa.头孢哌酮、头孢噻肟、拉氧头孢和羧苄西林与妥布霉素联合应用对铜绿假单胞菌的比较协同活性。
Antimicrob Agents Chemother. 1981 Feb;19(2):332-4. doi: 10.1128/AAC.19.2.332.