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β-内酰胺类抗生素组合对脆弱拟杆菌的体外抗菌作用。

Antimicrobial effect of beta-lactam antibiotic combinations against Bacteroides fragilis in vitro.

作者信息

Bansal M B, Thadepalli H

出版信息

Antimicrob Agents Chemother. 1983 Jan;23(1):166-8. doi: 10.1128/AAC.23.1.166.

DOI:10.1128/AAC.23.1.166
PMID:6830206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC184636/
Abstract

Carbenicillin, piperacillin, and mezlocillin, when combined with cefoxitin, exhibited synergism against 20, 13, and 10 isolates of Bacteroides fragilis, respectively, and no antagonism was observed in 19 of 20 strains. These results suggest that if beta-lactamase was induced from B. fragilis by cefoxitin, it was ineffective against the antibiotics tested.

摘要

羧苄西林、哌拉西林和美洛西林与头孢西丁联合使用时，分别对20株、13株和10株脆弱拟杆菌表现出协同作用，并且在20株菌株中有19株未观察到拮抗作用。这些结果表明，如果头孢西丁诱导脆弱拟杆菌产生β-内酰胺酶，那么该酶对所测试的抗生素无效。

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本文引用的文献

1
SYNERGISTIC ACTION OF PENICILLINS AND CEPHALOSPORINS AGAINST PSEUDOMONAS PYOCYANEA.青霉素与头孢菌素对绿脓杆菌的协同作用
Nature. 1964 Dec 12;204:1066-9. doi: 10.1038/2041066a0.
2
In vitro antagonism of beta-lactam antibiotics by cefoxitin.头孢西丁对β-内酰胺类抗生素的体外拮抗作用。
Antimicrob Agents Chemother. 1982 Jun;21(6):968-75. doi: 10.1128/AAC.21.6.968.
3
In vitro and in vivo antibacterial effects of combinations of beta-lactam antibiotics.β-内酰胺类抗生素组合的体外和体内抗菌作用
Antimicrob Agents Chemother. 1981 Apr;19(4):634-8. doi: 10.1128/AAC.19.4.634.
4
Combination of mezlocillin and azlocillin with cephalosporin antibiotics: cefoxitin, cefoperazone, cefotaxime and moxalactam.
J Antimicrob Chemother. 1982 Jan;9 Suppl A:101-6. doi: 10.1093/jac/9.suppl_a.101.
5
Bacteriological antagonism between acylureidopenicillins and cephalosporins.酰脲类青霉素与头孢菌素之间的细菌学拮抗作用。
J Antimicrob Chemother. 1982 Jan;9 Suppl A:31-4. doi: 10.1093/jac/9.suppl_a.31.