地构叶茎的化学成分。

Chemical constituents of the stems of Celastrus rugosus.

机构信息

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

出版信息

Arch Pharm Res. 2013 Nov;36(11):1291-301. doi: 10.1007/s12272-013-0145-z. Epub 2013 May 28.

Abstract

Two new sesquiterpene pyridine alkaloids rugosusines A and B (1 and 2), and thirty-one known compounds were isolated from the stems of Celastrus rugosus. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HR-ESI-MS and 2D NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The cytotoxicities of these compounds were tested against SKOV3 and MGC-803 cell lines by CCK-8 method.

摘要

从南蛇藤（Celastrus rugosus）茎中分离得到了两个新的倍半萜吡啶生物碱 rugosusines A 和 B（1 和 2），以及三十一个已知化合物。通过详细的光谱分析，包括 HR-ESI-MS 和 2D NMR 光谱数据，确定了新化合物的结构。所有化合物均首次从该植物中分离得到。通过 CCK-8 法测定了这些化合物对 SKOV3 和 MGC-803 细胞系的细胞毒性。