Xue Bin, Ganti Ketaki, Rabionet Alejandro, Banks Lawrence, Uversky Vladimir N
Department of Molecular Medicine, University of South Florida, 12901 Bruce B. Downs Blvd. MDC07, Tampa, Florida 33612, USA.
Curr Pharm Des. 2014;20(8):1274-92. doi: 10.2174/13816128113199990072.
Intrinsically disordered proteins (IDPs) and proteins with long intrinsically disordered protein regions (IDPRs) lack ordered structure but are involved in a multitude of biological processes, where they often serve as major regulators and controllers of various functions of their binding partners. Furthermore, IDPs/IDPRs are often related to the pathogenesis of various diseases, including cancer. Intrinsic disorder confers multiple functional advantages to its carriers. As a result, due to their functional versatility and structural plasticity, IDPs and IDPRs are common in various proteomes, including proteomes of different pathological organisms. Viruses are "well-educated" users of various aspects of intrinsic disorder for their advantage. These small but highly efficient invaders broadly use intrinsic disorder to overrun the host organism's defense system, as well as to seize and overrun host systems and pathways forcing them to work for the virus needs, to ensure accommodation of viruses to their variable and often hostile habitats, and to promote and support the economic usage of the viral genetic material. Human papillomaviruses (HPVs), with their tiny proteomes (the entire HPV genome includes just eight open reading frames), intricate life cycle, and ability to either cause benign papillomas/warts or promote the development of carcinomas of the genital tract, head and neck and epidermis, attracted considerable attention of researchers. This review analyzes the plentitude and demeanor of intrinsic disorder in proteins from HPVs and their cellular targets.
内在无序蛋白质（IDP）和具有长内在无序蛋白质区域（IDPR）的蛋白质缺乏有序结构，但参与众多生物过程，在这些过程中它们常作为其结合伴侣各种功能的主要调节者和控制者。此外，IDP/IDPR常与包括癌症在内的各种疾病的发病机制相关。内在无序赋予其载体多种功能优势。因此，由于其功能的多样性和结构的可塑性，IDP和IDPR在各种蛋白质组中很常见，包括不同病理生物体的蛋白质组。病毒是内在无序各方面优势的“熟练使用者”。这些微小但高效的入侵者广泛利用内在无序来突破宿主生物体的防御系统，以及夺取并掌控宿主系统和途径，迫使它们为病毒的需求服务，以确保病毒适应其多变且往往恶劣的生存环境，并促进和支持病毒遗传物质的高效利用。人乳头瘤病毒（HPV）以其微小的蛋白质组（整个HPV基因组仅包含八个开放阅读框）、复杂的生命周期以及引发良性乳头瘤/疣或促进生殖道、头颈部和表皮癌发展的能力，引起了研究人员的极大关注。本综述分析了HPV及其细胞靶点蛋白质中内在无序的丰富程度和表现。
