Department of Microbial Pathogenicity Mechanisms; Hans-Knoell-Institute; Jena, Germany.
Virulence. 2013 Jul 1;4(5):391-9. doi: 10.4161/viru.25199. Epub 2013 May 28.
The Candida genus expresses virulence factors that, when combined with immunosuppression and other risk factors, can cause different manifestations of oral candidiasis. The treatment of mucosal infections caused by Candida and the elucidation of the disease process have proven challenging. Therefore, the study of experimentally induced oral candidiasis in rats and mice is useful to clarify the etiopathology of this condition, improve diagnosis, and search for new therapeutic options because the disease process in these animals is similar to that of human candidiasis lesions. Here, we describe and discuss new studies involving rat and mouse models of oral candidiasis with respect to methods for inducing experimental infection, methods for evaluating the development of experimental candidiasis, and new treatment strategies for oral candidiasis.
念珠菌属表达毒力因子，当与免疫抑制和其他危险因素结合时，可引起不同表现的口腔念珠菌病。念珠菌引起的黏膜感染的治疗和疾病过程的阐明已被证明具有挑战性。因此，研究大鼠和小鼠的实验性诱导性口腔念珠菌病对于阐明该疾病的病因病理学、改善诊断和寻找新的治疗选择非常有用，因为这些动物的疾病过程与人类念珠菌病病变相似。在这里，我们描述和讨论了涉及大鼠和小鼠口腔念珠菌病模型的新研究，涉及实验性感染的诱导方法、实验性念珠菌病发展的评估方法以及口腔念珠菌病的新治疗策略。
