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视网膜的磁共振成像:从小鼠到人类。

Magnetic resonance imaging of the retina: from mice to men.

作者信息

Duong Timothy Q

机构信息

South Texas Veterans Health Care System, Research Imaging Institute, Department of Ophthalmology, University of Texas Health Science Center, San Antonio, Texas, USA.

出版信息

Magn Reson Med. 2014 Apr;71(4):1526-30. doi: 10.1002/mrm.24797. Epub 2013 May 28.

DOI:10.1002/mrm.24797
PMID:23716429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3783549/
Abstract

This mini-review provides an overview of magnetic resonance imaging (MRI) applications to study rodent, cat, non-human primate, and human retinas. These techniques include T(1) - and T(2) -weighted anatomical, diffusion, blood flow, blood volume, blood-oxygenation level dependent, manganese-enhanced, physiological, and functional MRI. Applications to study the retinas in diabetic retinopathy, glaucoma, and retinal degeneration are also reviewed. MRI offers some unique advantages compared with existing imaging techniques and has the potential to further our understanding of physiology and function in healthy and diseased retinas.

摘要

本综述概述了磁共振成像(MRI)在研究啮齿动物、猫、非人灵长类动物和人类视网膜方面的应用。这些技术包括T(1)加权和T(2)加权解剖成像、扩散成像、血流成像、血容量成像、血氧水平依赖性功能磁共振成像、锰增强磁共振成像、生理磁共振成像和功能磁共振成像。还综述了MRI在糖尿病视网膜病变、青光眼和视网膜变性中视网膜研究的应用。与现有成像技术相比,MRI具有一些独特的优势,并且有潜力进一步加深我们对健康和患病视网膜的生理及功能的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4292/3783549/04caa98f27cb/nihms479174f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4292/3783549/ea8a69a51c28/nihms479174f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4292/3783549/04caa98f27cb/nihms479174f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4292/3783549/ea8a69a51c28/nihms479174f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4292/3783549/04caa98f27cb/nihms479174f2.jpg

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Decreased retinal-choroidal blood flow in retinitis pigmentosa as measured by MRI.通过磁共振成像测量发现色素性视网膜炎患者视网膜 - 脉络膜血流减少。
Doc Ophthalmol. 2013 Jun;126(3):187-97. doi: 10.1007/s10633-013-9374-1. Epub 2013 Feb 14.
2
Human vitreous: MR imaging of oxygen partial pressure.人眼玻璃体:氧分压的磁共振成像。
Radiology. 2013 Mar;266(3):905-11. doi: 10.1148/radiol.12120777. Epub 2012 Dec 6.
3
Light-dependent changes in outer retinal water diffusion in rats in vivo.大鼠活体中外侧视网膜水扩散的光依赖性变化。
Aberrant Neurovascular Coupling in Diabetic Retinopathy Using Arterial Spin Labeling (ASL) and Functional Magnetic Resonance Imaging (fMRI) methods.
使用动脉自旋标记(ASL)和功能磁共振成像(fMRI)方法研究糖尿病视网膜病变中的异常神经血管耦合。
Diabetes Metab Syndr Obes. 2024 Jul 26;17:2809-2822. doi: 10.2147/DMSO.S465103. eCollection 2024.
4
Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms.同步功能磁共振眼部成像、视频检眼镜检查和眼表成像揭示了人类大脑和眼睛的搏动机制。
Sci Rep. 2024 Jan 26;14(1):2250. doi: 10.1038/s41598-023-51069-1.
5
An analysis of the correlation between diabetic retinopathy and preretinal oxygen tension using three-dimensional spoiled gradient-recalled echo sequence imaging.采用三维扰相梯度回波序列成像分析糖尿病视网膜病变与视网膜前氧张力的相关性。
BMC Med Imaging. 2022 Jul 5;22(1):121. doi: 10.1186/s12880-022-00846-x.
6
Morphometric and Microstructural Changes During Murine Retinal Development Characterized Using In Vivo Optical Coherence Tomography.利用活体光学相干断层扫描技术对小鼠视网膜发育过程中的形态和微观结构变化进行研究。
Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):20. doi: 10.1167/iovs.62.13.20.
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Invest Ophthalmol Vis Sci. 2016 Mar;57(3):826-31. doi: 10.1167/iovs.15-18291.
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Mol Vis. 2012;18:2561-xxx. Epub 2012 Oct 19.
4
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Magn Reson Med. 2012 Oct;68(4):1202-10. doi: 10.1002/mrm.24123. Epub 2011 Dec 28.