Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul 139-742, Korea.
J Ginseng Res. 2011 Sep;35(3):331-8. doi: 10.5142/jgr.2011.35.3.331.
Red ginseng (RG, the extract of Panax ginseng Meyer) has various biological and psychological activities and may also alleviate fatigue-related disorders. The present study was undertaken to evaluate what kind of fatigue red ginseng alleviate. Animals were orally administered with 50, 100, 200, 400 mg/kg of RG for 7 days. Before experiments were performed. Physiological stress (swimming, rotarod, and wire test) are behavioral parameters used to represent physical fatigue. Restraint stress and electric field test to a certain degree, induce psychological fatigue in animals. Plasma concentration of lactate and corticosterone (CORT) were also measured after these behavioral assays. RG supplementation (100 mg/kg) increased movement duration and rearing frequency of restrainted mice in comparison with control. 100 and 200 mg/kg of RG increased swimming time in cold water (8±4℃) while at 100 mg/kg, RG increased electric field crossing over frequencies. 50, 100 and 200 mg/kg RG prolonged running time on the rotarod and at 100 mg/kg, it increased balancing time on the wire. RG at those doses also reduced falling frequencies. RG supplementation decreased plasma CORT levels, which was increased by stress. Lactate levels were not significantly altered. These results suggest that RG supplementation can alleviate more the damages induced by psychological than physical fatigue.
红参（RG，人参提取物）具有多种生物和心理活性，也可能缓解与疲劳相关的疾病。本研究旨在评估红参缓解哪种疲劳。动物连续 7 天口服给予 50、100、200、400mg/kg 的 RG。在进行实验之前。生理应激（游泳、转棒和线试验）是用于表示体力疲劳的行为参数。束缚应激和电场试验在一定程度上诱导动物产生心理疲劳。在这些行为测定后，还测量了血浆中乳酸和皮质酮（CORT）的浓度。与对照组相比，100mg/kg 的 RG 补充剂增加了束缚小鼠的运动时间和站立次数。100 和 200mg/kg 的 RG 增加了冷水（8±4℃）中的游泳时间，而 100mg/kg 的 RG 增加了电场穿越频率。50、100 和 200mg/kg 的 RG 延长了在转棒上的跑步时间，而在 100mg/kg 的 RG 延长了在钢丝上的平衡时间。这些剂量的 RG 还降低了跌落频率。RG 补充剂降低了应激引起的血浆 CORT 水平，而对乳酸水平没有显著影响。这些结果表明，RG 补充剂可以缓解更多的心理疲劳引起的损害，而不是体力疲劳。
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