Department of Microbiology and Washington National Primate Research Center, University of Washington, Box 358070, Seattle, Washington 98195, USA.
Nat Rev Microbiol. 2013 Jul;11(7):455-66. doi: 10.1038/nrmicro3036. Epub 2013 Jun 3.
High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.
高通量分子谱分析和计算生物学正在改变病毒学的面貌，使人们对宿主在病毒发病机制中的重要性有了新的认识，并为更好的诊断、治疗和疫苗提供了前所未有的机会。在这里，我们提供了系统病毒学发展的一个快照，从全局基因表达谱分析和疾病结果的特征，到基于几何的计算方法，这些方法有望产生新的治疗靶点、个性化医学和更深入地了解病毒如何引起疾病。为了实现这些目标，移液器和培养皿需要与数学和计算生物学的力量结合起来。
