Wani Sajad Ahmad, Sahu Amit Ranjan, Saxena Shikha, Hussain Shahid, Pandey Aruna, Kanchan Sonam, Sahoo Aditya Prasad, Mishra Bina, Tiwari Ashok Kumar, Mishra Bishnu Prasad, Gandham Ravi Kumar, Singh Raj Kumar
Division of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, India.
Division of Biological Products, ICAR-Indian Veterinary Research Institute, Izatnagar 243122, India.
Gene Rep. 2016 Dec;5:23-29. doi: 10.1016/j.genrep.2016.08.002. Epub 2016 Aug 9.
Systems biology is an interdisciplinary research field in life sciences, which involves a comprehensive and quantitative analysis of the interactions between all of the components of biological systems over time. For the past 50 years the discipline of virology has overly focused on the pathogen itself. However, we now know that the host response is equally or more important in defining the eventual pathological outcome of infection. Systems biology has in recent years been increasingly recognised for its importance to infectious disease research. Host-virus interactions can be better understood by taking into account the dynamical molecular networks that constitute a biological system. To decipher the pathobiological mechanisms of any disease requires a deep knowledge of how multiple and concurrent signal-transduction pathways operate and are deregulated. Hence the intricacies of signalling pathways can be dissected only by system level approaches.
系统生物学是生命科学中的一个跨学科研究领域，它涉及对生物系统所有组成部分之间随时间变化的相互作用进行全面和定量分析。在过去的50年里，病毒学学科过度关注病原体本身。然而，我们现在知道，宿主反应在确定感染的最终病理结果方面同样重要或更为重要。近年来，系统生物学因其对传染病研究的重要性而越来越受到认可。通过考虑构成生物系统的动态分子网络，可以更好地理解宿主-病毒相互作用。要解读任何疾病的病理生物学机制，需要深入了解多个并发信号转导途径是如何运作以及失调的。因此，信号通路的复杂性只能通过系统层面的方法来剖析。
