Department of Neurology, University of California, San Francisco, 400 Parnassus Avenue, Box 0348, San Francisco, CA 94143, USA.
J Neural Transm (Vienna). 2012 Jun;119(6):697-9. doi: 10.1007/s00702-011-0761-z. Epub 2012 Jan 10.
Although amphetamine drugs can damage dopaminergic axons, it is unknown whether chronic treatment with amphetamine increases the risk of developing Parkinson's disease (PD). Of 1,152 consecutive PD patients, 3 had a prior diagnosis of narcolepsy. This rate is five times higher than expected (p = 0.02). These patients had typical onset of narcolepsy and underwent treatment with amphetamine. Although preliminary, this observation raises the possibility that some factors intrinsic to narcolepsy or its treatment may be a risk factor for PD.
尽管安非他命类药物会损伤多巴胺能轴突，但目前仍不清楚长期使用安非他命是否会增加帕金森病（PD）的发病风险。在 1152 例连续 PD 患者中，有 3 例先前被诊断为发作性睡病。这一比例是预期的五倍（p = 0.02）。这些患者具有典型的发作性睡病发病特征，并接受了安非他命治疗。尽管这一观察结果尚属初步，但它提示了发作性睡病或其治疗中某些内在因素可能是 PD 的一个危险因素。
