Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Sleep. 2013 Jun 1;36(6):955-7. doi: 10.5665/sleep.2734.
Short-sleep insomnia is associated with increased risk of diabetes. The role of altered insulin secretion and action in this association is poorly understood.
Observational study.
Academic clinical research center.
Nondiabetic individuals with insomnia (mean [standard deviation] age 48 [9] y, body mass index 25.6 [3.9] kg/m(2)) with ≤ 6 h (short sleep, n = 14) and > 6 h of sleep (n = 14) during overnight laboratory polysomnography.
Standard oral glucose testing was used to assess glucose tolerance, beta-cell function (homeostasis model assessment [HOMA-B]; second-phase insulin secretion) and insulin resistance (HOMA-IR; insulin sensitivity index). There was no significant difference in hemoglobin A1C and fasting or 2-h blood glucose concentrations between sleep groups. Short-sleep insomnia sufferers had lower fasting and postchallenge serum insulin concentrations associated with lower estimates of fasting and glucose-stimulated insulin secretion, and increased insulin sensitivity.
Individuals with short-sleep insomnia appear to have higher indices of systemic insulin sensitivity and secrete less insulin without changes in overall glucose tolerance.
短睡眠失眠与糖尿病风险增加有关。胰岛素分泌和作用改变在这种关联中的作用尚不清楚。
观察性研究。
学术临床研究中心。
非糖尿病失眠者（平均[标准差]年龄 48[9]岁，体重指数 25.6[3.9]kg/m2），夜间实验室多导睡眠图记录的睡眠时间≤6 小时（短睡眠，n=14）和>6 小时（n=14）。
标准口服葡萄糖耐量试验用于评估葡萄糖耐量、β细胞功能（稳态模型评估[HOMA-B]；第二相胰岛素分泌）和胰岛素抵抗（HOMA-IR；胰岛素敏感性指数）。睡眠组之间的血红蛋白 A1C 和空腹或 2 小时血糖浓度无显著差异。短睡眠失眠者的空腹和餐后血清胰岛素浓度较低，与空腹和葡萄糖刺激的胰岛素分泌估计值较低以及胰岛素敏感性增加有关。
短睡眠失眠者的全身胰岛素敏感性指数似乎较高，胰岛素分泌较少，但总体葡萄糖耐量无变化。
