Université Paris Descartes, Paris, France.
Cogn Neurodyn. 2012 Jun;6(3):251-7. doi: 10.1007/s11571-011-9177-6. Epub 2011 Oct 22.
Synaptic plasticity is thought to be the basis of learning and memory, but it is mostly studied on the timescale of mere minutes. This review discusses synaptic consolidation, a process that enables synapses to retain their strength for a much longer time (days to years), instead of returning to their original value. The process involves specific plasticity-related proteins, and depends on the dopamine D1/D5 receptors. Here, we review the research on synaptic consolidation, describing electrophysiology experiments, recent modeling work, as well as behavioral correlates.
突触可塑性被认为是学习和记忆的基础，但大多在数分钟的时间尺度上进行研究。这篇综述讨论了突触巩固，这是一个使突触能够保持更长时间（数天到数年）的强度而不是恢复到原来的强度的过程。该过程涉及特定的与可塑性相关的蛋白质，并依赖于多巴胺 D1/D5 受体。在这里，我们回顾了突触巩固的研究，描述了电生理学实验、最近的建模工作以及行为相关性。
