突触巩固：从突触到行为建模。
Synaptic consolidation: from synapses to behavioral modeling.
机构信息
School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland.
School of Computer and Communication Sciences and School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne EPFL, Switzerland
出版信息
J Neurosci. 2015 Jan 21;35(3):1319-34. doi: 10.1523/JNEUROSCI.3989-14.2015.
Abstract
Synaptic plasticity, a key process for memory formation, manifests itself across different time scales ranging from a few seconds for plasticity induction up to hours or even years for consolidation and memory retention. We developed a three-layered model of synaptic consolidation that accounts for data across a large range of experimental conditions. Consolidation occurs in the model through the interaction of the synaptic efficacy with a scaffolding variable by a read-write process mediated by a tagging-related variable. Plasticity-inducing stimuli modify the efficacy, but the state of tag and scaffold can only change if a write protection mechanism is overcome. Our model makes a link from depotentiation protocols in vitro to behavioral results regarding the influence of novelty on inhibitory avoidance memory in rats.
摘要
突触可塑性是记忆形成的关键过程，其表现形式跨越不同的时间尺度，从几秒钟的可塑性诱导到数小时甚至数年的巩固和记忆保留。我们开发了一种三层突触巩固模型，该模型可以解释在广泛的实验条件下的数据。在模型中，通过标记相关变量介导的读写过程，突触效能与支架变量相互作用发生巩固。诱导可塑性的刺激会改变效能，但只有克服写入保护机制，标签和支架的状态才能改变。我们的模型将体外去极化方案与关于新奇性对大鼠抑制性回避记忆影响的行为结果联系起来。
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