Department of Ophthalmology, Glick Eye Institute, Indiana University Medical Center, Indianapolis, IN, USA.
J Glaucoma. 2013 Jun-Jul;22 Suppl 5(0 5):S46-8. doi: 10.1097/IJG.0b013e3182934b6b.
Glaucomatous damage has been described as a slowly progressive neuronal degenerative process along the visual pathway. Decreased cerebral and ocular blood flow as well as impaired vascular autoregulation has been identified in glaucoma and have been shown to correlate with visual field loss. In low-tension glaucoma patients, diffuse cerebral ischemic changes have been detected through magnetic resonance imaging. Given these findings, it seems that for some patients, glaucomatous damage may be the ocular manifestation of a more widespread vascular abnormality involving the brain rather than a separate process isolated only to the eye and its immediate vasculature.
青光眼性损害被描述为沿着视觉通路的一种缓慢进行性的神经元退行性病变。青光眼患者的脑和眼血流减少以及血管自动调节功能受损已被确定，并与视野丧失相关。在低眼压性青光眼患者中，磁共振成像已检测到弥漫性脑缺血改变。鉴于这些发现，对于某些患者来说，青光眼性损害可能是眼部表现，提示存在更广泛的血管异常，累及大脑，而不仅仅是眼睛及其直接血管系统的孤立性病变。
