Department of Ophthalmology, Medical University of Vienna, 1090, Vienna, Austria.
Curr Diab Rep. 2013 Aug;13(4):469-75. doi: 10.1007/s11892-013-0389-5.
The retinal vasculature is an extremely complex system that is adapted to support the metabolic demands of the retinal structures, but on the other hand maintain the optimal optical qualities of this tissue. Through histological studies and clinical studies using fluorescein angiography we have learned a lot about the retinal vasculature in its physiological state and in different diseases, but both of these study methods have serious limitations that limit their extensive application in healthy subjects or in patients with early disease. In this current review we will present early observations about the retinal vasculature from several novel noninvasive imaging modalities like adaptive optics SLO, retinal functional imager, adaptive optics OCT and Doppler OCT. Some of these instruments allow a more detailed in vivo examination of the retinal vasculature than fluorescein angiography without its potentially serious side effects, thus better allowing us to further study retinal vascular homeostasis in healthy subjects and to identify preclinical changes in early disease stages.
视网膜血管系统是一个极其复杂的系统，它适应于支持视网膜结构的代谢需求，但同时又保持了这种组织的最佳光学质量。通过组织学研究和使用荧光素血管造影的临床研究，我们已经了解了很多关于视网膜血管系统在生理状态和不同疾病中的情况，但这两种研究方法都有严重的局限性，限制了它们在健康受试者或早期疾病患者中的广泛应用。在这篇综述中，我们将介绍几种新的非侵入性成像方式，如自适应光学 SLO、视网膜功能成像仪、自适应光学 OCT 和多普勒 OCT，对视网膜血管系统的早期观察结果。这些仪器中的一些可以在没有潜在严重副作用的情况下，比荧光素血管造影更详细地检查视网膜血管，从而更好地帮助我们进一步研究健康受试者的视网膜血管内稳态，并在早期疾病阶段识别临床前变化。
