• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

联合抗真菌治疗在治疗尖端赛多孢中枢神经系统感染中的应用

Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections.

作者信息

Henao-Martínez Andrés F, Castillo-Mancilla José R, Barron Michelle A, Nichol Aran Cunningham

机构信息

Division of Infectious Diseases, University of Colorado Denver, 12700 E. 19th Avenue, Mail Stop B168, Aurora, CO 80045, USA.

出版信息

Case Rep Infect Dis. 2013;2013:589490. doi: 10.1155/2013/589490. Epub 2013 Apr 29.

DOI:10.1155/2013/589490
PMID:23738164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657419/
Abstract

Treatment of Scedosporium apiospermum central nervous system (CNS) infection typically consists of an azole in combination with surgical debridement. This approach requires prolonged treatment and carries a high associated mortality. We present two cases of the successful treatment of S. apiospermum CNS infections with the combination of voriconazole and terbinafine.

摘要

尖端赛多孢子菌中枢神经系统（CNS）感染的治疗通常包括使用唑类药物联合手术清创。这种方法需要长期治疗且伴有较高的相关死亡率。我们报告两例使用伏立康唑和特比萘芬联合成功治疗尖端赛多孢子菌CNS感染的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/21925853d19e/CRIM.ID2013-589490.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/a598b4f2c9d8/CRIM.ID2013-589490.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/396a3e2b4a37/CRIM.ID2013-589490.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/21925853d19e/CRIM.ID2013-589490.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/a598b4f2c9d8/CRIM.ID2013-589490.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/396a3e2b4a37/CRIM.ID2013-589490.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f18/3657419/21925853d19e/CRIM.ID2013-589490.003.jpg

相似文献

1
Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections.联合抗真菌治疗在治疗尖端赛多孢中枢神经系统感染中的应用
Case Rep Infect Dis. 2013;2013:589490. doi: 10.1155/2013/589490. Epub 2013 Apr 29.
2
Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature.复发性阿皮尤斯德氏霉足菌肿经手术切除和特比萘芬治疗成功治愈：一例报告并文献复习
Ann Clin Microbiol Antimicrob. 2017 Apr 14;16(1):31. doi: 10.1186/s12941-017-0195-z.
3
Cure of orthopaedic infection with Scedosporium prolificans, using voriconazole plus terbinafine, without the need for radical surgery.使用伏立康唑加特比萘芬治疗多育赛多孢菌引起的骨科感染，无需进行根治性手术。
Mycoses. 2003 Jun;46(5-6):233-6. doi: 10.1046/j.1439-0507.2003.00878.x.
4
fungemia successfully treated with voriconazole and terbinafine.伏立康唑和特比萘芬成功治疗真菌血症。
IDCases. 2020 Aug 8;22:e00928. doi: 10.1016/j.idcr.2020.e00928. eCollection 2020.
5
Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review.后Tenon囊下注射曲安奈德后感染性阿皮瘤状瓶霉性巩膜炎：病例报告及文献复习
BMC Ophthalmol. 2018 Feb 13;18(1):40. doi: 10.1186/s12886-018-0707-4.
6
Successful salvage treatment of Scedosporium apiospermum keratitis with topical voriconazole after failure of natamycin.在那他霉素治疗失败后，局部应用伏立康唑成功挽救治疗尖端赛多孢菌角膜炎。
Ann Pharmacother. 2009 Jun;43(6):1139-42. doi: 10.1345/aph.1M008. Epub 2009 May 12.
7
Scedosporium Apiospermum: Rare Cause of Brain Abscess in an Immunocompetent Patient.尖端赛多孢：免疫功能正常患者脑脓肿的罕见病因。
Neurol India. 2020 Jul-Aug;68(4):906-909. doi: 10.4103/0028-3886.293486.
8
Multiple Scedosporium apiospermum brain abscesses after near-drowning successfully treated with surgery and long-term voriconazole: a case report.近乎溺亡后发生多株尖端赛多孢菌脑脓肿，经手术及长期伏立康唑治疗成功：一例报告
Mycoses. 2007 Nov;50(6):512-6. doi: 10.1111/j.1439-0507.2007.01410.x.
9
Disseminated central nervous system infection after lung transplantation: A case report with successful recovery.肺移植术后播散性中枢神经系统感染：一例成功康复的病例报告
Med Mycol Case Rep. 2019 Mar 16;24:37-40. doi: 10.1016/j.mmcr.2019.03.003. eCollection 2019 Jun.
10
Intravitreal voriconazole for the treatment of endogenous endophthalmitis caused by Scedosporium apiospermum.玻璃体内注射伏立康唑治疗由尖端赛多孢菌引起的内源性眼内炎。
Clin Exp Ophthalmol. 2007 May-Jun;35(4):382-5. doi: 10.1111/j.1442-9071.2007.01493.x.

引用本文的文献

1
Pulmonary Infiltrates in a Non-Cystic Fibrosis Bronchiectasis Patient: A Case Report.非囊性纤维化支气管扩张症患者的肺部浸润：一例报告
J Clin Med. 2025 Aug 21;14(16):5914. doi: 10.3390/jcm14165914.
2
Systemic Infection Affecting Multiple Sites After Near-Drowning: A Case Report.近乎溺亡后多部位系统性感染：一例报告
Infect Drug Resist. 2024 Dec 20;17:5739-5744. doi: 10.2147/IDR.S483524. eCollection 2024.
3
Emerging Fungal Infections of the Central Nervous System in the Past Decade: A Literature Review.过去十年中枢神经系统新出现的真菌感染：文献综述

本文引用的文献

1
Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.棘孢木霉属和拟青霉属种的种特异性抗真菌药敏模式。
Antimicrob Agents Chemother. 2012 May;56(5):2635-42. doi: 10.1128/AAC.05910-11. Epub 2012 Jan 30.
2
Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.囊性纤维化患者双肺移植后播散性节菱孢/拟青霉感染。
J Clin Microbiol. 2010 May;48(5):1978-82. doi: 10.1128/JCM.01840-09. Epub 2010 Mar 10.
3
Voriconazole concentrations and outcome of invasive fungal infections.
Infect Dis Rep. 2024 Oct 9;16(5):952-976. doi: 10.3390/idr16050076.
4
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections.鞘内孢子菌病和节孢子菌病：这些难以治疗的罕见霉菌感染的现代观点。
Clin Microbiol Rev. 2024 Jun 13;37(2):e0000423. doi: 10.1128/cmr.00004-23. Epub 2024 Mar 29.
5
Update on therapeutic approaches for invasive fungal infections in adults.成人侵袭性真菌感染治疗方法的最新进展。
Ther Adv Infect Dis. 2024 Jan 20;11:20499361231224980. doi: 10.1177/20499361231224980. eCollection 2024 Jan-Dec.
6
Unusual Fungal Endocarditis Causing Disseminated Infection After Renal Transplant.肾移植后引起播散性感染的罕见真菌性心内膜炎
Cureus. 2023 May 11;15(5):e38896. doi: 10.7759/cureus.38896. eCollection 2023 May.
7
Rapid Diagnosis of Central Nervous System Scedosporiosis by Specific Quantitative Polymerase Chain Reaction Applied to Formalin-Fixed, Paraffin-Embedded Tissue.应用于福尔马林固定、石蜡包埋组织的特异性定量聚合酶链反应对中枢神经系统赛多孢子菌病的快速诊断
J Fungi (Basel). 2021 Dec 27;8(1):19. doi: 10.3390/jof8010019.
8
fungemia successfully treated with voriconazole and terbinafine.伏立康唑和特比萘芬成功治疗真菌血症。
IDCases. 2020 Aug 8;22:e00928. doi: 10.1016/j.idcr.2020.e00928. eCollection 2020.
9
Cerebral phaeohyphomycosis caused by spp.: A case report.由[具体菌种名称]引起的脑暗色丝孢霉病：一例报告
Med Mycol Case Rep. 2019 Dec 3;27:11-13. doi: 10.1016/j.mmcr.2019.12.001. eCollection 2020 Mar.
10
Scedosporium apiospermum infection of the urinary system with a review of treatment options and cases in the literature.泌尿系统的伪阿利什霉感染及治疗选择与文献病例综述
Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12804. Epub 2017 Dec 21.
伏立康唑浓度与侵袭性真菌感染结局。
Clin Microbiol Infect. 2010 Jul;16(7):927-33. doi: 10.1111/j.1469-0691.2009.02990.x. Epub 2009 Oct 20.
4
Treatment of scedosporiosis with voriconazole: clinical experience with 107 patients.伏立康唑治疗足放线病菌病：107例患者的临床经验
Antimicrob Agents Chemother. 2008 May;52(5):1743-50. doi: 10.1128/AAC.01388-07. Epub 2008 Jan 22.
5
Voriconazole therapeutic drug monitoring in patients with invasive mycoses improves efficacy and safety outcomes.对侵袭性真菌病患者进行伏立康唑治疗药物监测可改善疗效和安全性结果。
Clin Infect Dis. 2008 Jan 15;46(2):201-11. doi: 10.1086/524669.
6
Infection with Scedosporium apiospermum and S. prolificans, Australia.澳大利亚的伪阿利什霉和多育赛多孢感染。
Emerg Infect Dis. 2007 Aug;13(8):1170-7. doi: 10.3201/eid1308.060576.
7
Multifocal Scedosporium apiospermum spondylitis in a cystic fibrosis patient.一名囊性纤维化患者的多灶性尖端赛多孢菌脊柱炎。
J Cyst Fibros. 2008 Jan;7(1):89-91. doi: 10.1016/j.jcf.2007.05.003. Epub 2007 Jun 13.
8
Successful control of Scedosporium prolificans septic arthritis and probable osteomyelitis without radical surgery in a long-term renal transplant recipient.一名长期肾移植受者在未进行根治性手术的情况下成功控制多育赛多孢菌性脓毒性关节炎和可能的骨髓炎。
Transpl Infect Dis. 2008 Feb;10(1):63-5. doi: 10.1111/j.1399-3062.2007.00240.x. Epub 2007 Apr 11.
9
Scedosporium apiospermum (Pseudoallescheria boydii) infection in lung transplant recipients.肺移植受者中的阿皮瘤状瓶霉（博伊德拟阿利什霉）感染
J Heart Lung Transplant. 2007 Apr;26(4):350-6. doi: 10.1016/j.healun.2007.01.011. Epub 2007 Mar 2.
10
Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine.一名慢性肉芽肿病患者发生多育赛多孢菌脑脓肿：伏立康唑与特比萘芬联合治疗成功
Scand J Infect Dis. 2007;39(1):87-90. doi: 10.1080/00365540600786564.